Reactome | MRE11 binds cytosolic DNA

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MRE11 binds cytosolic DNA Show undefined attributes

authored	[InstanceEdit:3065946] Shamovsky, V, 2013-02-06
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:3204310] Shamovsky, V, 2013-02-28
dbId	3204303
displayName	MRE11 binds cytosolic DNA
edited	[InstanceEdit:3465604] Shamovsky, V, 2013-05-17
eventOf	[Pathway:R-HSA-1834949] Cytosolic sensors of pathogen-associated DNA - Homo sapiens
input	[SimpleEntity:R-ALL-874088] Double-stranded DNA [cytosol] [EntityWithAccessionedSequence:R-HSA-3204309] MRE11A [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3204306] DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	MRE11 binds cytosolic DNA
orthologousEvent	[Reaction:R-MMU-3204303] MRE11 binds cytosolic DNA - Mus musculus [Reaction:R-PFA-3204303] MRE11 binds cytosolic DNA - Plasmodium falciparum [Reaction:R-SCE-3204303] MRE11 binds cytosolic DNA - Saccharomyces cerevisiae [Reaction:R-SPO-3204303] MRE11 binds cytosolic DNA - Schizosaccharomyces pombe [Reaction:R-DDI-3204303] MRE11 binds cytosolic DNA - Dictyostelium discoideum [Reaction:R-CEL-3204303] MRE11 binds cytosolic DNA - Caenorhabditis elegans [Reaction:R-DME-3204303] MRE11 binds cytosolic DNA - Drosophila melanogaster [Reaction:R-GGA-3204303] MRE11 binds cytosolic DNA - Gallus gallus [Reaction:R-XTR-3204303] MRE11 binds cytosolic DNA - Xenopus tropicalis [Reaction:R-DRE-3204303] MRE11 binds cytosolic DNA - Danio rerio [Reaction:R-SSC-3204303] MRE11 binds cytosolic DNA - Sus scrofa [Reaction:R-BTA-3204303] MRE11 binds cytosolic DNA - Bos taurus [Reaction:R-CFA-3204303] MRE11 binds cytosolic DNA - Canis familiaris [Reaction:R-RNO-3204303] MRE11 binds cytosolic DNA - Rattus norvegicus
output	[Complex:R-HSA-3204308] MRE11:dsDNA [cytosol]
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3110284] D'Eustachio, P, 2013-02-11 [InstanceEdit:3597627] Jin, Lei, 2013-05-21 [InstanceEdit:3597624] Wu, Jiaxi, 2013-05-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3204303
summation	[Summation:3465585] DNA damage sensor, meiotic recombination 11 homolog A (MRE11...
updateTrackers	[UpdateTracker:9780827] Update Tracker - [Reaction:3204303] MRE11 binds cytosolic DNA - v62:[add_removeInput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9780827] Update Tracker - [Reaction:3204303] MRE11 binds cytosolic DNA - v62:[add_removeInput, modifyText]
(hasEvent)	[Pathway:R-HSA-1834949] Cytosolic sensors of pathogen-associated DNA