Reactome | MRE11 binds cytosolic DNA

MRE11 binds cytosolic DNA

Stable Identifier

R-HSA-3204303

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

DNA damage sensor, meiotic recombination 11 homolog A (MRE11) has been shown to function as a cytosolic sensor of dsDNA. The observations that MRE11 mediates recognition of dsDNA rather than pathogens suggest that the biological significance of MRE11-mediated intracellular DNA recognition is to respond to damaged host cells, rather than defense against foreign pathogens (Kondo T et al. 2013). Cells with a mutation of MRE11 gene derived from a patient with ataxia-telangiectasia-like disorder, and cells in which Mre11 was knocked down, had defects in dsDNA-induced type I IFN production (Kondo T et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
23388631	DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking Kawai, T, Ishii, KJ, Akira, S, Kobayashi, J, Barber, GN, Saitoh, T, Kondo, T, Komatsu, K, Maruyama, K	Proc. Natl. Acad. Sci. U.S.A.	2013