Reactome | MRE11 binds cytosolic DNA

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10692571
displayName	MRE11 binds cytosolic DNA
eventOf	[Pathway:R-XTR-1834949] Cytosolic sensors of pathogen-associated DNA - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-3204303] MRE11 binds cytosolic DNA - Homo sapiens
input	[SimpleEntity:R-ALL-874088] Double-stranded DNA [cytosol] [EntityWithAccessionedSequence:R-XTR-3204309] mre11 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	MRE11 binds cytosolic DNA
output	[Complex:R-XTR-3204308] MRE11:dsDNA [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-3204303
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-XTR-1834949] Cytosolic sensors of pathogen-associated DNA
(inferredTo)	[Reaction:R-HSA-3204303] MRE11 binds cytosolic DNA

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