Reactome | MMACHC decyanates CNCbl

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MMACHC decyanates CNCbl Show undefined attributes

catalystActivity	[CatalystActivity:10959818] cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity of MMACHC [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10959820
displayName	MMACHC decyanates CNCbl
eventOf	[Pathway:R-CEL-9759218] Cobalamin (Cbl) metabolism - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-3149494] MMACHC:cob(II)alamin binds MMADHC - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-3149519] MMACHC decyanates CNCbl - Homo sapiens
input	2 × [SimpleEntity:R-ALL-3149505] CNCbl [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] 2 × [EntityWithAccessionedSequence:R-CEL-2980949] MMACHC [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	MMACHC decyanates CNCbl MMACHC reductively decyanates CNCbl 2 apo--(cyanocobalamin reductase) + 2 cyanocob(III)alamin + H(+) + NADPH => 2 cob(II)alamin--(cyanocobalamin reductase) + 2 hydrogen cyanide + NADP(+)
output	2 × [SimpleEntity:R-ALL-1130611] HCN [cytosol] 2 × [Complex:R-CEL-3095903] MMACHC:cob(II)alamin [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-3149519
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-9759218] Cobalamin (Cbl) metabolism
(precedingEvent)	[Reaction:R-CEL-3149494] MMACHC:cob(II)alamin binds MMADHC
(inferredTo)	[Reaction:R-HSA-3149519] MMACHC decyanates CNCbl

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