Reactome | DEx/H-box helicases activate type I IFN and inflammatory cytokines production

DEx/H-box helicases activate type I IFN and inflammatory cytokines production

Stable Identifier

R-HSA-3134963

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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DEx/H-box helicases activate type I IFN and inflammatory cytokines production

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DHX36 and DHX9 are aspartate-glutamate-any amino acid aspartate/histidine (DExD/H) box helicase (DHX) proteins that localize in the cytosol. The DHX RNA helicases family includes a large number of proteins that are implicated in RNA metabolism. Members of this family, RIG-1 and MDA5, have been shown to sense a non-self RNA leading to type I IFN production. RNA helicases DHX36 and DHX9 were found to trigger host responses to non-self DNA in MyD88-dependent manner. DHX36 sensed CpG class A, while DHX9 sensed CpG class B. Both DHX36 and DHX9 were critical for antiviral immune responses in viral DNA-stimulated human plasmacytoid dendritic cells (pDC) (Kim T et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20696886	Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells Hanabuchi, S, Plumas, J, Pazhoor, S, Bover, L, Kim, T, Facchinetti, V, Zhang, Z, Chaperot, L, Liu, YJ, Bao, M, Qin, J	Proc. Natl. Acad. Sci. U.S.A.	2010