Reactome | SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA

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SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA Show undefined attributes

authored	[InstanceEdit:3004457] Orlic-Milacic, M, 2013-01-28
catalystActivity	[CatalystActivity:3000336] ubiquitin-protein transferase activity of p-8S,3T-BORA:SCF-beta-TrCp1/2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:3000338] Orlic-Milacic, M, 2013-01-24
dbId	3000335
displayName	SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA
edited	[InstanceEdit:3006289] Orlic-Milacic, M, 2013-01-29
eventOf	[Pathway:R-HSA-2565942] Regulation of PLK1 Activity at G2/M Transition - Homo sapiens
input	[Complex:R-HSA-3000340] p-8S,3T-BORA:SCF-beta-TrCp1/2 [cytosol] [DefinedSet:R-HSA-113595] Ub [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3000332] Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA
negativePrecedingEvent	[NegativePrecedingEvent:9764019] Futile Cycle: GTSE1 facilitates proteasome-mediated degradation of TP53 [NegativePrecedingEvent:9764046] Futile Cycle: Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 [NegativePrecedingEvent:9764049] Futile Cycle: Proteasome-mediated degradation of PolyUb-FBXL7
orthologousEvent	[Reaction:R-CEL-3000335] SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA - Caenorhabditis elegans [Reaction:R-DME-3000335] SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA - Drosophila melanogaster [Reaction:R-DRE-3000335] SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA - Danio rerio [Reaction:R-CFA-3000335] SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA - Canis familiaris [Reaction:R-RNO-3000335] SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA - Rattus norvegicus [Reaction:R-MMU-3000335] SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA - Mus musculus
output	[DefinedSet:R-HSA-1168601] (BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] [Complex:R-HSA-3000337] Ub-p-8S,3T-BORA [cytosol]
precedingEvent	[Reaction:R-HSA-3000339] Phosphorylated BORA binds SCF-beta-TrCp1/2 - Homo sapiens
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4410473] Bruinsma, Wytse, 2013-08-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3000335
summation	[Summation:3002840] SCF-beta-TrCP ubiquitin ligases promote ubiquitination and d...

Referrals

(hasEvent)	[Pathway:R-HSA-2565942] Regulation of PLK1 Activity at G2/M Transition
(precedingEvent)	[NegativePrecedingEvent:9764054] Futile Cycle: SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA

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