SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA

Stable Identifier
R-HSA-3000335
Type
Reaction
Species
Homo sapiens
Compartment
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SCF-beta-TrCP ubiquitin ligases promote ubiquitination and degradation of BORA phosphorylated by PLK1, and this is required for timely mitotic progression (Seki et al. 2008).

Literature References
PubMed ID Title Journal Year
18378770 Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression

Seki, A, Coppinger, JA, Yates, JR, Jang, CY, Fang, G, Du, H

J. Cell Biol. 2008
Participants
Participates
Catalyst Activity

ubiquitin-protein transferase activity of p-S252,S497,T501-BORA:SCF-beta-TrCp1/2 [cytosol]

Orthologous Events
Authored
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Created
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