SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA

Stable Identifier
R-HSA-3000335
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA
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SCF-beta-TrCP ubiquitin ligases promote ubiquitination and degradation of BORA phosphorylated by PLK1, and this is required for timely mitotic progression (Seki et al. 2008).
Literature References
PubMed ID Title Journal Year
18378770 Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression

Seki, A, Coppinger, JA, Du, H, Jang, CY, Yates, JR, Fang, G

J. Cell Biol. 2008
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Catalyst Activity

ubiquitin-protein transferase activity of p-8S,3T-BORA:SCF-beta-TrCp1/2 [cytosol]

Physical Entity
p-8S,3T-BORA:SCF-beta-TrCp1/2 [cytosol] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Orthologous Events
SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Caenorhabditis elegans)
SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Canis familiaris)
SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Danio rerio)
SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Drosophila melanogaster)
SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Mus musculus)
SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2013-01-29)
Reviewed
Bruinsma, W  (2013-08-21)
Created
Orlic-Milacic, M  (2013-01-25)
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