Reactome | VRK1/VRK2 phosphorylate BANF1

Schema > Reaction > Entries

VRK1/VRK2 phosphorylate BANF1 Show undefined attributes

authored	[InstanceEdit:2997493] Orlic-Milacic, M, 2013-01-22
catalystActivity	[CatalystActivity:2993909] protein serine/threonine kinase activity of VRK1/VRK2 [nucleoplasm]
category	transition
compartment	[Compartment:13231] nuclear envelope [Compartment:7660] nucleoplasm [Compartment:1598585] chromosome
created	[InstanceEdit:2993897] Orlic-Milacic, M, 2013-01-21
dbId	2993898
displayName	VRK1/VRK2 phosphorylate BANF1
edited	[InstanceEdit:2997529] Gillespie, ME, 2013-01-23
eventOf	[Pathway:R-HSA-2980766] Nuclear Envelope Breakdown - Homo sapiens
followingEvent	[Depolymerisation:R-HSA-5229194] Depolymerization of lamin filaments after PKC-mediated phosphorylation - Homo sapiens
input	6 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-2993900] EMD/TMPO/LEMD3/LEMD2:Lamin filaments:BANF1:Chromatin [nuclear envelope]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:180116] Protection of retroviral DNA from autointegration: involvement of a cellular factor [LiteratureReference:180139] A previously unidentified host protein protects retroviral DNA from autointegration [LiteratureReference:2993924] Barrier-to-autointegration factor (BAF) bridges DNA in a discrete, higher-order nucleoprotein complex [LiteratureReference:2993942] LAP2 binds to BAF.DNA complexes: requirement for the LEM domain and modulation by variable regions [LiteratureReference:2993939] Transcriptional repressor germ cell-less (GCL) and barrier to autointegration factor (BAF) compete for binding to emerin in vitro [LiteratureReference:2993950] Direct binding of nuclear membrane protein MAN1 to emerin in vitro and two modes of binding to barrier-to-autointegration factor [LiteratureReference:2993954] BAF is required for emerin assembly into the reforming nuclear envelope [LiteratureReference:2993934] LAP2alpha and BAF transiently localize to telomeres and specific regions on chromatin during nuclear assembly [LiteratureReference:2993943] The vaccinia-related kinases phosphorylate the N' terminus of BAF, regulating its interaction with DNA and its retention in the nucleus [LiteratureReference:2993944] Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis [LiteratureReference:2993929] Barrier-to-autointegration factor phosphorylation on Ser-4 regulates emerin binding to lamin A in vitro and emerin localization in vivo [LiteratureReference:2995368] Caenorhabditis elegans BAF-1 and its kinase VRK-1 participate directly in post-mitotic nuclear envelope assembly [LiteratureReference:3065977] The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines [LiteratureReference:3067331] LEM2 is a novel MAN1-related inner nuclear membrane protein associated with A-type lamins
maxDepth	1
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	VRK1/VRK2 phosphorylate BANF1
orthologousEvent	[Reaction:R-BTA-2993898] VRK1/VRK2 phosphorylate BANF1 - Bos taurus [Reaction:R-XTR-2993898] VRK1/VRK2 phosphorylate BANF1 - Xenopus tropicalis [Reaction:R-SSC-2993898] VRK1/VRK2 phosphorylate BANF1 - Sus scrofa [Reaction:R-CFA-2993898] VRK1/VRK2 phosphorylate BANF1 - Canis familiaris [Reaction:R-RNO-2993898] VRK1/VRK2 phosphorylate BANF1 - Rattus norvegicus [Reaction:R-MMU-2993898] VRK1/VRK2 phosphorylate BANF1 - Mus musculus
output	6 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [DefinedSet:R-ALL-2537690] Chromatin [chromosome] [Complex:R-HSA-2993911] EMD/TMPO/LEMD3/LEMD2:Lamin filaments [nuclear envelope] [Complex:R-HSA-2993912] p-T2,T3,S4-BANF1 [nucleoplasm]
releaseDate	2013-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3110279] Gorj�n�cz, M�ty�s, 2013-01-30 [InstanceEdit:3110278] Mattaj, Iain W, 2013-01-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2993898
summation	[Summation:2993910] In mitotic prophase, chromatin detaches from the nuclear env...
updateTrackers	[UpdateTracker:9777996] Update Tracker - [Reaction:2993898] VRK1/VRK2 phosphorylate BANF1 - v68:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9777996] Update Tracker - [Reaction:2993898] VRK1/VRK2 phosphorylate BANF1 - v68:[modifyText]
(hasEvent)	[Pathway:R-HSA-2980766] Nuclear Envelope Breakdown
(precedingEvent)	[Depolymerisation:R-HSA-5229194] Depolymerization of lamin filaments after PKC-mediated phosphorylation

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