Reactome | SENP1,2,5 proteolytically process SUMO3

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SENP1,2,5 proteolytically process SUMO3 Show undefined attributes

authored	[InstanceEdit:2984266] May, B, 2013-01-16
catalystActivity	[CatalystActivity:2990845] SUMO-specific endopeptidase activity of SENP1,2,5 [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9644146] SUMO-specific endopeptidase activity of SENP1,2,5 [nucleoplasm] Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:2993794] May, B, 2013-01-19
dbId	2993763
displayName	SENP1,2,5 proteolytically process SUMO3
edited	[InstanceEdit:2984266] May, B, 2013-01-16
eventOf	[Pathway:R-HSA-3065679] SUMO is proteolytically processed - Homo sapiens
followingEvent	[Reaction:R-HSA-2993781] Conjugation of SUMO3 to UBA2:SAE1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-2990830] SUMO3(1-103) [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3214960] Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1 [LiteratureReference:2984273] Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3 [LiteratureReference:3214974] Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs [LiteratureReference:2984291] Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1 [LiteratureReference:2984315] Desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) through the cytoplasmic-nuclear shuttling of the SUMO-specific protease SENP1 [LiteratureReference:2984289] Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex [LiteratureReference:3299587] Association of the human SUMO-1 protease SENP2 with the nuclear pore [LiteratureReference:3299590] Nucleocytoplasmic shuttling modulates activity and ubiquitination-dependent turnover of SUMO-specific protease 2 [LiteratureReference:3299592] The SUMO-specific protease SENP5 is required for cell division
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	SENP1,2,5 proteolytically process SUMO3
orthologousEvent	[Reaction:R-DDI-2993763] SENP1,2,5 proteolytically process SUMO3 - Dictyostelium discoideum [Reaction:R-DME-2993763] SENP1,2,5 proteolytically process SUMO3 - Drosophila melanogaster [Reaction:R-XTR-2993763] SENP1,2,5 proteolytically process SUMO3 - Xenopus tropicalis [Reaction:R-DRE-2993763] SENP1,2,5 proteolytically process SUMO3 - Danio rerio [Reaction:R-SSC-2993763] SENP1,2,5 proteolytically process SUMO3 - Sus scrofa [Reaction:R-BTA-2993763] SENP1,2,5 proteolytically process SUMO3 - Bos taurus [Reaction:R-CFA-2993763] SENP1,2,5 proteolytically process SUMO3 - Canis familiaris [Reaction:R-RNO-2993763] SENP1,2,5 proteolytically process SUMO3 - Rattus norvegicus [Reaction:R-MMU-2993763] SENP1,2,5 proteolytically process SUMO3 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-2984269] SUMO3 [nucleoplasm]
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3448698] Garg, Amit K, 2013-05-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2993763
summation	[Summation:3222553] The SUMO3 precursor has 11 extra residues at the C-terminus ...

Referrals

(hasEvent)	[Pathway:R-HSA-3065679] SUMO is proteolytically processed
(precedingEvent)	[Reaction:R-HSA-2993781] Conjugation of SUMO3 to UBA2:SAE1

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