Reactome | SENP1,2,5 proteolytically process SUMO3

SENP1,2,5 proteolytically process SUMO3

Stable Identifier

R-HSA-2993763

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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The SUMO3 precursor has 11 extra residues at the C-terminus which can be removed endoproteolytically by SENP1, SENP2, or SENP5 (Zheng and Au, 2005, Gong and Yeh 2006, Mikolajczyk et al. 2007). The order of processing activity is: SENP1 greater than SENP2 greater than SENP5 (Mikolajczyk et al. 2007). Overall, processing of SUMO3 is the lowest of any SUMO (Mikolajczyk et al. 2007). SENP1 and SENP2 shuttle between the nucleus and cytosol and are predominantly nuclear (Bailey and O'Hare 2004, Kim et al. 2005, Zhang et al. 2002, Hang and Dasso 2002, Itahana et al. 2006). SENP5 is located in the nucleolus (Di Bacco et al. 2006, Gong and Yeh 2006).

Literature References

PubMed ID	Title	Journal	Year
17591783	Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs Békés, M, Drag, M, Ronai, Z, Cao, JT, Mikolajczyk, J, Salvesen, GS	J. Biol. Chem.	2007
14563852	Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1 O'Hare, P, Bailey, D	J. Biol. Chem.	2004
12192048	Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex Zhang, H, Matunis, MJ, Saitoh, H	Mol. Cell. Biol.	2002
16608850	Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3 Yeh, ET, Gong, L	J. Biol. Chem.	2006
16738315	The SUMO-specific protease SENP5 is required for cell division Ploegh, H, Catic, A, Gill, G, Lee, HY, Ouyang, J, Di Bacco, A	Mol. Cell. Biol.	2006
16253240	Desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) through the cytoplasmic-nuclear shuttling of the SUMO-specific protease SENP1 Lee, SJ, Kim, Y, Sung, KS, Choi, CY, Kim, YO, Kim, YH	FEBS Lett.	2005
16738331	Nucleocytoplasmic shuttling modulates activity and ubiquitination-dependent turnover of SUMO-specific protease 2 Yeh, ET, Zhang, Y, Itahana, Y	Mol. Cell. Biol.	2006
11896061	Association of the human SUMO-1 protease SENP2 with the nuclear pore Dasso, M, Hang, J	J. Biol. Chem.	2002
15487983	Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1 Au, SW, Xu, Z	Biochem. J.	2005