ANOs transport cytosolic Cl- to extracellular region

Stable Identifier
Reaction [transition]
Homo sapiens
Cytosolic Cl- is transported to extracellular region by ANOs
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Calcium-activated chloride channels (CaCCs) are ubiquitously expressed and implicated in physiological processes such as sensory transduction, fertilization, epithelial secretion, and smooth muscle contraction. The anoctamin family of transmembrane proteins (ANO, TMEM16) belong to CaCCs and have been shown to transport Cl- ions when activated by intracellular Ca2+ (Galietta 2009, Huang et al. 2012). There are currently 10 members, ANO1-10, all having a similar structure, with eight putative transmembrane domains and cytosolic amino- and carboxy-termini. ANO1 and 2 possess Ca2+ activated Cl- transport activity (Yang et al. 2008, Scudieri et al. 2012) while the remaining members also show some demonstrable activity (Tian et al. 2012). All CLCAs contain a consensus cleavage motif which is recognised by an internal zincin metalloprotease domain within the N terminus. Self-proteolysis within the secretory pathway yields N- and C-terminal fragments, a step critical for CLCA activation of calcium-activated chloride channels (CaCCs) mediated through the N-terminal fragment (Yurtsever et al. 2012).
Literature References
PubMed ID Title Journal Year
22946059 Anoctamins are a family of Ca2+ activated Cl- channels

Kunzelmann, K, Schreiber, R, Tian, Y

J. Cell. Sci. 2012
18724360 TMEM16A confers receptor-activated calcium-dependent chloride conductance

Oh, U, Shim, WS, Shin, YK, Lee, B, Cho, Y, Raouf, R, Kim, BM, Cho, H, Koo, JY, Yang, YD, Lee, J, Park, SP, Tak, MH

Nature 2008
21984732 The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels

Galietta, LJ, Ferrera, L, Scudieri, P, Sondo, E

Exp. Physiol. 2012
Catalyst Activity

chloride channel activity of ANOs [plasma membrane]

This event is regulated
Orthologous Events
Cross References
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