ANOs transport cytosolic Cl- to extracellular region

Stable Identifier
R-HSA-2684901
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Cytosolic Cl- is transported to extracellular region by ANOs
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Calcium-activated chloride channels (CaCCs) are ubiquitously expressed and implicated in physiological processes such as sensory transduction, fertilization, epithelial secretion, and smooth muscle contraction. The anoctamin family of transmembrane proteins (ANO, TMEM16) belong to CaCCs and have been shown to transport Cl- ions when activated by intracellular Ca2+ (Galietta 2009, Huang et al. 2012). There are currently 10 members, ANO1-10, all having a similar structure, with eight putative transmembrane domains and cytosolic amino- and carboxy-termini. ANO1 and 2 possess Ca2+ activated Cl- transport activity (Yang et al. 2008, Scudieri et al. 2012) while the remaining members also show some demonstrable activity (Tian et al. 2012).

Literature References
PubMed ID Title Journal Year
18724360 TMEM16A confers receptor-activated calcium-dependent chloride conductance

Yang, YD, Cho, H, Koo, JY, Tak, MH, Cho, Y, Shim, WS, Park, SP, Lee, J, Lee, B, Kim, BM, Raouf, R, Shin, YK, Oh, U

Nature 2008
22946059 Anoctamins are a family of Ca2+ activated Cl- channels

Tian, Y, Schreiber, R, Kunzelmann, K

J. Cell. Sci. 2012
21984732 The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels

Scudieri, P, Sondo, E, Ferrera, L, Galietta, LJ

Exp. Physiol. 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
intracellular calcium activated chloride channel activity of ANOs [plasma membrane]
Physical Entity
Activity
This event is regulated
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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