JAK2 Phosphoryates STAT3 in Response to Leptin

Stable Identifier
R-HSA-2671850
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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JAK2 Phosphoryates STAT3 in Response to Leptin
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Phosphorylated JAK2 in the LEP:LEPR:JAK2:STAT3 complex phosphorylates STAT3 at tyrosine-705 (Bjorbaek et al. 1997).
Literature References
PubMed ID Title Journal Year
9405487 Divergent signaling capacities of the long and short isoforms of the leptin receptor

Bjørbaek, C, Uotani, S, da Silva, B, Flier, JS

J. Biol. Chem. 1997
Participants
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Output
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as an event of
Catalyst Activity

protein tyrosine kinase activity of LEP:p-LEPR:p-JAK2:STAT3 [plasma membrane]

Physical Entity
LEP:p-LEPR:p-JAK2:STAT3 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Inferred From
Jak2 Phosphorylates Stat3 in Response to Leptin (Mus musculus)
Authored
May, B  (2012-11-15)
Reviewed
Scherer, T  (2013-08-31)
Gonzalez-Perez, RR  (2013-10-26)
Created
May, B  (2012-11-26)
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