Reactome | KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel

Schema > Reaction > Entries

KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel Show undefined attributes

catalystActivity	[CatalystActivity:10355507] ATP binding activity of KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10355521
displayName	KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel
eventOf	[Pathway:R-BTA-422356] Regulation of insulin secretion - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-265645] Calcium Influx through Voltage-gated Calcium Channels - Bos taurus
inferredFrom	[Reaction:R-HSA-265682] KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel - Homo sapiens
input	4 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-BTA-265734] KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel Closing of Inward Rectifying, ATP-sensitive Potassium Channels (KATP channels)
output	[Complex:R-BTA-265746] KCNJ11:ATP tetramer:ABCC8 tetramer [plasma membrane] 4 × [Complex:R-ALL-6790050] Mg2+:ADP [cytosol]
regulatedBy	[PositiveRegulation:10355522] Positive regulation by 'PKA catalytic subunit [cytosol]' [PositiveRegulation:10355523] Positive regulation by 'RAPGEF4:cAMP Complex [plasma membrane]' [PositiveRegulation:10355524] Positive regulation by 'RAPGEF3:cAMP complex [plasma membrane]' [NegativeRegulation:R-HSA-5339572] Negative regulation by 'Zn2+ [extracellular region]' [PositiveRegulation:R-HSA-5683249] Positive regulation by 'Glc [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-265682
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-422356] Regulation of insulin secretion
(precedingEvent)	[Reaction:R-BTA-265645] Calcium Influx through Voltage-gated Calcium Channels
(inferredTo)	[Reaction:R-HSA-265682] KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel

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