Reactome | Arachidonate is oxidised to 5S-HpETE by ALOX5

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Arachidonate is oxidised to 5S-HpETE by ALOX5 Show undefined attributes

catalystActivity	[CatalystActivity:10578261] oxidoreductase activity of ALOX5:ALOX5AP:LTC4S [nuclear envelope]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:13231] nuclear envelope
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10578263
displayName	Arachidonate is oxidised to 5S-HpETE by ALOX5
eventOf	[Pathway:R-DRE-2142688] Synthesis of 5-eicosatetraenoic acids - Danio rerio [Pathway:R-DRE-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-266051] 5S-HpETE is dehydrated to LTA4 by ALOX5 - Danio rerio
inferredFrom	[Reaction:R-HSA-265296] Arachidonate is oxidised to 5S-HpETE by ALOX5 - Homo sapiens
input	[SimpleEntity:R-ALL-29768] AA [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Arachidonate is oxidised to 5S-HpETE by ALOX5 (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate Oxidation of arachidonic acid to 5-HpETE
output	[SimpleEntity:R-ALL-266010] 5S-HpETE [cytosol]
precedingEvent	[Reaction:R-DRE-429016] ALOX5 is phosphorylated by MAPKAP2 - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-265296
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) [Pathway:R-DRE-2142688] Synthesis of 5-eicosatetraenoic acids
(precedingEvent)	[Reaction:R-DRE-266051] 5S-HpETE is dehydrated to LTA4 by ALOX5
(inferredTo)	[Reaction:R-HSA-265296] Arachidonate is oxidised to 5S-HpETE by ALOX5

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