Reactome | Autoubiquitination of phospho-COP1(Ser-387 )

Autoubiquitination of phospho-COP1(Ser-387 )

Stable Identifier

R-HSA-264444

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - G1/S DNA Damage Checkpoints (Homo sapiens)
    - p53-Dependent G1/S DNA damage checkpoint (Homo sapiens)
      - p53-Dependent G1 DNA Damage Response (Homo sapiens)
        
        Stabilization of p53 (Homo sapiens)
        
        Autodegradation of the E3 ubiquitin ligase COP1 (Homo sapiens)
        
        Autoubiquitination of phospho-COP1(Ser-387 ) (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Autoubiquitination of phospho-COP1(Ser-387 )

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

ATM phosphorylation promotes autoubiquitination of COP1 in vitro (Dornan et al., 2006). The number of ubiquitin molecules shown in this reaction is set arbitrarily at 4.

Literature References

PubMed ID	Title	Journal	Year
16931761	ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage Dornan, D, Shimizu, H, Mah, A, Dudhela, T, Eby, M, O'Rourke, K, Seshagiri, S, Dixit, VM	Science	2006