Reactome | Formation of soluble VTN:C5b-C9

Schema > Reaction > Entries

Formation of soluble VTN:C5b-C9 Show undefined attributes

authored	[InstanceEdit:2530435] Shamovsky, V, 2012-10-17
category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:2530435] Shamovsky, V, 2012-10-17
dbId	2530429
displayName	Formation of soluble VTN:C5b-C9
edited	[InstanceEdit:3632872] Shamovsky, V, 2013-05-28
eventOf	[Pathway:R-HSA-977606] Regulation of Complement cascade - Homo sapiens
input	[Complex:R-HSA-173713] C8 [extracellular region] [EntityWithAccessionedSequence:R-HSA-173717] C9(22-559) [extracellular region] [Complex:R-HSA-2530437] VTN:C5b:C6:C7 [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2530457] Complement inhibition by human vitronectin involves non-heparin binding domains [LiteratureReference:2530434] Complement S-protein (vitronectin) is associated with cytolytic membrane-bound C5b-9 complexes [LiteratureReference:2530455] SC5b-7, SC5b-8 and SC5b-9 complexes of complement: ultrastructure and localization of the S-protein (vitronectin) within the macromolecules
maxDepth	1
modified	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
name	Formation of soluble VTN:C5b-C9
orthologousEvent	[Reaction:R-GGA-2132088] Vitronectin prevents C9 polymerization - Gallus gallus [Reaction:R-DRE-2530429] Formation of soluble VTN:C5b-C9 - Danio rerio [Reaction:R-SSC-2530429] Formation of soluble VTN:C5b-C9 - Sus scrofa [Reaction:R-BTA-2530429] Formation of soluble VTN:C5b-C9 - Bos taurus [Reaction:R-CFA-2530429] Formation of soluble VTN:C5b-C9 - Canis familiaris [Reaction:R-MMU-2530429] Formation of soluble VTN:C5b-C9 - Mus musculus
output	[Complex:R-HSA-2530442] VTN:C5b:C6:C7:C8:C9 [extracellular region]
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3632871] Bradley, DT
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2530429
summation	[Summation:2530464] Complement proteins C8 and C9 can bind to VTN:C5b:C6:C7 to f...

Referrals

(hasEvent)

[Pathway:R-HSA-977606] Regulation of Complement cascade