Reactome | Formation of soluble VTN:C5b-C9

Formation of soluble VTN:C5b-C9

Stable Identifier

R-HSA-2530429

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Complement proteins C8 and C9 can bind to VTN:C5b:C6:C7 to form soluble C5b-C9 complex in plasma. The vitronectin binding to C5b-C9 complex prevents C9 polymerization by rendering it water-soluble and lytic inactive.

Literature References

PubMed ID	Title	Journal	Year
7542572	Complement inhibition by human vitronectin involves non-heparin binding domains Charlesworth, JA, Morris, CA, Sheehan, M, Pussell, BA	Clin. Exp. Immunol.	1995
2466593	Complement S-protein (vitronectin) is associated with cytolytic membrane-bound C5b-9 complexes Halstensen, TS, Hugo, F, Preissner, KT, Käflein, R, Mollnes, TE, Bhakdi, S	Clin. Exp. Immunol.	1988
2465906	SC5b-7, SC5b-8 and SC5b-9 complexes of complement: ultrastructure and localization of the S-protein (vitronectin) within the macromolecules Podack, ER, Müller-Eberhard, HJ, Preissner, KP	Eur. J. Immunol.	1989