Formation of soluble VTN:C5b-C9

Stable Identifier
R-HSA-2530429
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Complement proteins C8 and C9 can bind to VTN:C5b:C6:C7 to form soluble C5b-C9 complex in plasma. The vitronectin binding to C5b-C9 complex prevents C9 polymerization by rendering it water-soluble and lytic inactive.
Literature References
PubMed ID Title Journal Year
7542572 Complement inhibition by human vitronectin involves non-heparin binding domains

Charlesworth, JA, Morris, CA, Sheehan, M, Pussell, BA

Clin. Exp. Immunol. 1995
2466593 Complement S-protein (vitronectin) is associated with cytolytic membrane-bound C5b-9 complexes

Halstensen, TS, Hugo, F, Preissner, KT, Käflein, R, Mollnes, TE, Bhakdi, S

Clin. Exp. Immunol. 1988
2465906 SC5b-7, SC5b-8 and SC5b-9 complexes of complement: ultrastructure and localization of the S-protein (vitronectin) within the macromolecules

Podack, ER, Müller-Eberhard, HJ, Preissner, KP

Eur. J. Immunol. 1989
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