Formation of soluble VTN:C5b-C9

Stable Identifier
R-HSA-2530429
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Complement proteins C8 and C9 can bind to VTN:C5b:C6:C7 to form soluble C5b-C9 complex in plasma. The vitronectin binding to C5b-C9 complex prevents C9 polymerization by rendering it water-soluble and lytic inactive.

Literature References
PubMed ID Title Journal Year
2466593 Complement S-protein (vitronectin) is associated with cytolytic membrane-bound C5b-9 complexes

Bhakdi, S, Käflein, R, Halstensen, TS, Hugo, F, Preissner, KT, Mollnes, TE

Clin. Exp. Immunol. 1988
7542572 Complement inhibition by human vitronectin involves non-heparin binding domains

Sheehan, M, Morris, CA, Pussell, BA, Charlesworth, JA

Clin. Exp. Immunol. 1995
2465906 SC5b-7, SC5b-8 and SC5b-9 complexes of complement: ultrastructure and localization of the S-protein (vitronectin) within the macromolecules

Preissner, KP, Podack, ER, Müller-Eberhard, HJ

Eur. J. Immunol. 1989
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created