Fibrillin-1 degradation by ELANE

Stable Identifier
R-HSA-2514823
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Fibrillin-1 degradation by neutrophil elastase
ReviewStatus
5/5
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Fibrillin-1 degradation by ELANE
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Fibrillin-1, the major structural component of microfibrils (Kielty et al. 2005), can be degraded by neutrophil elastase (ELANE) (Kielty et al. 1994).

Participants
Input
Output
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as an event of
Catalyst Activity

serine-type endopeptidase activity of ELANE [extracellular region]

Physical Entity
ELANE [extracellular region] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Inferred From
Degradation of fibrilin-1 by Elane (Bos taurus)
Authored
Jupe, S  (2012-08-08)
Reviewed
Ricard-Blum, S  (2013-08-13)
Created
Jupe, S  (2012-10-10)
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