Reactome | SCARB1:ligand is endocytosed

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SCARB1:ligand is endocytosed Show undefined attributes

authored	[InstanceEdit:3222522] Neyen, Claudine, 2013-03-22 [InstanceEdit:3000476] May, B, 2013-01-26
category	omitted
compartment	[Compartment:24337] endocytic vesicle membrane [Compartment:876] plasma membrane
created	[InstanceEdit:2512801] May, B, 2012-10-07
dbId	2512800
displayName	SCARB1:ligand is endocytosed
edited	[InstanceEdit:2512772] May, B, 2012-10-07
eventOf	[Pathway:R-HSA-3000471] Scavenging by Class B Receptors - Homo sapiens
input	[Complex:R-HSA-2512792] SCARB1:Endocytosed Ligand [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2197601] CLA-1 is an 85-kD plasma membrane glycoprotein that acts as a high-affinity receptor for both native (HDL, LDL, and VLDL) and modified (OxLDL and AcLDL) lipoproteins [LiteratureReference:2197623] Uptake and fate of class B scavenger receptor ligands in HepG2 cells [LiteratureReference:2197596] Serum amyloid A binding to CLA-1 (CD36 and LIMPII analogous-1) mediates serum amyloid A protein-induced activation of ERK1/2 and p38 mitogen-activated protein kinases [LiteratureReference:2197628] Binding and internalization of lipopolysaccharide by Cla-1, a human orthologue of rodent scavenger receptor B1 [LiteratureReference:349651] Characterization of CLA-1, a human homologue of rodent scavenger receptor BI, as a receptor for high density lipoprotein and apoptotic thymocytes [LiteratureReference:3221854] High density lipoprotein uptake by scavenger receptor SR-BII [LiteratureReference:3221872] Endocytosis is not required for the selective lipid uptake mediated by murine SR-BI [LiteratureReference:3221886] SR-BI-mediated high density lipoprotein (HDL) endocytosis leads to HDL resecretion facilitating cholesterol efflux [LiteratureReference:3221930] The inhibition of endocytosis affects HDL-lipid uptake mediated by the human scavenger receptor class B type I [LiteratureReference:3221906] Murine SR-BI, a high density lipoprotein receptor that mediates selective lipid uptake, is N-glycosylated and fatty acylated and colocalizes with plasma membrane caveolae [LiteratureReference:3221942] High density lipoprotein endocytosis by scavenger receptor SR-BII is clathrin-dependent and requires a carboxyl-terminal dileucine motif [LiteratureReference:3221950] Distinct mechanisms for OxLDL uptake and cellular trafficking by class B scavenger receptors CD36 and SR-BI
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	SCARB1:ligand is endocytosed
orthologousEvent	[BlackBoxEvent:R-RNO-2512800] SCARB1:ligand is endocytosed - Rattus norvegicus [BlackBoxEvent:R-GGA-2512800] SCARB1:ligand is endocytosed - Gallus gallus [BlackBoxEvent:R-SSC-2512800] SCARB1:ligand is endocytosed - Sus scrofa [BlackBoxEvent:R-BTA-2512800] SCARB1:ligand is endocytosed - Bos taurus [BlackBoxEvent:R-CFA-2512800] SCARB1:ligand is endocytosed - Canis familiaris [BlackBoxEvent:R-MMU-2512800] SCARB1:ligand is endocytosed - Mus musculus
output	[Complex:R-HSA-2512799] SCARB1:Endocytosed Ligand [endocytic vesicle membrane]
precedingEvent	[Reaction:R-HSA-2197646] SCARB1 (SR-BI, CLA-1) binds ligands - Homo sapiens
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3222522] Neyen, Claudine, 2013-03-22
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-2512800
summation	[Summation:2512835] The SCARB1 (SR-BI, SR-BII):ligand complex is endocytosed (Ca...

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(hasEvent)

[Pathway:R-HSA-3000471] Scavenging by Class B Receptors

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