SCARB1:ligand is endocytosed

Stable Identifier
R-HSA-2512800
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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The SCARB1 (SR-BI, SR-BII):ligand complex is endocytosed (Calvo et al. 1997, Murao et al. 1997, Rhainds et al. 1999, Vishnyakova et al. 2003, Baranova et al. 2005, Eckhardt et al. 2004) but selective lipid uptake from lipoprotein particles does not require SR-BI endocytosis in mouse (Nieland et al. 2005) but is partly dependent on endocytosis in human (Zhang et al. 2007). HDL particles are resecreted after lipid unloading in the endocytic pathway (Pagler et al. 2006; Zhang et al. 2007). SR-BI colocalizes with caveolae (inferred from mouse, Babitt et al. 1997) while SR-BII, an alternatively spliced form of SCARB1, localizes to clathrin-coated pits due to a dileucine motif in the cytosolic tail (inferred from mouse, Eckhardt et al. 2006). Endocytosis of oxidized LDL by SR-BI is independent of caveolae, microtubules, and actin cytoskeleton (inferred from mouse, Sun et al. 2007).

Literature References
PubMed ID Title Journal Year
16488891 SR-BI-mediated high density lipoprotein (HDL) endocytosis leads to HDL resecretion facilitating cholesterol efflux

Pagler, TA, Rhode, S, Neuhofer, A, Laggner, H, Strobl, W, Hinterndorfer, C, Volf, I, Pavelka, M, Eckhardt, ER, van der Westhuyzen, DR, Schütz, GJ, Stangl, H

J. Biol. Chem. 2006
17876058 Distinct mechanisms for OxLDL uptake and cellular trafficking by class B scavenger receptors CD36 and SR-BI

Sun, B, Boyanovsky, BB, Connelly, MA, Shridas, P, van der Westhuyzen, DR, Webb, NR

J. Lipid Res. 2007
14726519 High density lipoprotein uptake by scavenger receptor SR-BII

Eckhardt, ER, Cai, L, Sun, B, Webb, NR, van der Westhuyzen, DR

J. Biol. Chem. 2004
12651854 Binding and internalization of lipopolysaccharide by Cla-1, a human orthologue of rodent scavenger receptor B1

Vishnyakova, TG, Bocharov, AV, Baranova, IN, Chen, Z, Remaley, AT, Csako, G, Eggerman, TL, Patterson, AP

J Biol Chem 2003
15576377 Serum amyloid A binding to CLA-1 (CD36 and LIMPII analogous-1) mediates serum amyloid A protein-induced activation of ERK1/2 and p38 mitogen-activated protein kinases

Baranova, IN, Vishnyakova, TG, Bocharov, AV, Kurlander, R, Chen, Z, Kimelman, ML, Remaley, AT, Csako, G, Thomas, F, Eggerman, TL, Patterson, AP

J Biol Chem 2005
17710648 The inhibition of endocytosis affects HDL-lipid uptake mediated by the human scavenger receptor class B type I

Zhang, Y, Ahmed, AM, Tran, TL, Lin, J, McFarlane, N, Boreham, DR, Igdoura, SA, Truant, R, Trigatti, BL

Mol. Membr. Biol. 2007
16368683 High density lipoprotein endocytosis by scavenger receptor SR-BII is clathrin-dependent and requires a carboxyl-terminal dileucine motif

Eckhardt, ER, Cai, L, Shetty, S, Zhao, Z, Szanto, A, Webb, NR, van der Westhuyzen, DR

J. Biol. Chem. 2006
9211901 Characterization of CLA-1, a human homologue of rodent scavenger receptor BI, as a receptor for high density lipoprotein and apoptotic thymocytes

Murao, K, Terpstra, V, Green, SR, Kondratenko, N, Steinberg, D, Quehenberger, O

J Biol Chem 1997
10103054 Uptake and fate of class B scavenger receptor ligands in HepG2 cells

Rhainds, D, Falstrault, L, Tremblay, C, Brissette, L

Eur J Biochem 1999
9148942 Murine SR-BI, a high density lipoprotein receptor that mediates selective lipid uptake, is N-glycosylated and fatty acylated and colocalizes with plasma membrane caveolae

Babitt, J, Trigatti, B, Rigotti, A, Smart, EJ, Anderson, RG, Xu, S, Krieger, M

J. Biol. Chem. 1997
15866482 Endocytosis is not required for the selective lipid uptake mediated by murine SR-BI

Nieland, TJ, Ehrlich, M, Krieger, M, Kirchhausen, T

Biochim. Biophys. Acta 2005
9409200 CLA-1 is an 85-kD plasma membrane glycoprotein that acts as a high-affinity receptor for both native (HDL, LDL, and VLDL) and modified (OxLDL and AcLDL) lipoproteins

Calvo, D, Gómez-Coronado, D, Lasunción, MA, Vega, MA

Arterioscler Thromb Vasc Biol 1997
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