Reactome | NUDT16 hydrolyses IDP to IMP

Schema > Reaction > Entries

NUDT16 hydrolyses IDP to IMP Show undefined attributes

authored	[InstanceEdit:2509814] D'Eustachio, P, 2012-10-05
catalystActivity	[CatalystActivity:2509812] IDP phosphatase activity of NUDT16 dimer [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643590] IDP phosphatase activity of NUDT16 dimer [nucleoplasm] NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:2509808] D'Eustachio, P, 2012-10-05
crossReference	[DatabaseIdentifier:12667796] RHEA:35208 [DatabaseIdentifier:9976351] RHEA:35208
dbId	2509816
displayName	NUDT16 hydrolyses IDP to IMP
edited	[InstanceEdit:2509814] D'Eustachio, P, 2012-10-05
eventOf	[Pathway:R-HSA-2393930] Phosphate bond hydrolysis by NUDT proteins - Homo sapiens
input	[SimpleEntity:R-ALL-113518] H2O [nucleoplasm] [SimpleEntity:R-ALL-2509811] IDP [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2509797] NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest [LiteratureReference:2509799] Metal determines efficiency and substrate specificity of the nuclear NUDIX decapping proteins X29 and H29K (Nudt16)
maxDepth	1
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	NUDT16 hydrolyses IDP to IMP IDP + H2O => IMP + phosphate + H(+)
orthologousEvent	[Reaction:R-XTR-2509816] NUDT16 hydrolyses IDP to IMP - Xenopus tropicalis [Reaction:R-DRE-2509816] NUDT16 hydrolyses IDP to IMP - Danio rerio [Reaction:R-SSC-2509816] NUDT16 hydrolyses IDP to IMP - Sus scrofa [Reaction:R-BTA-2509816] NUDT16 hydrolyses IDP to IMP - Bos taurus [Reaction:R-CFA-2509816] NUDT16 hydrolyses IDP to IMP - Canis familiaris [Reaction:R-RNO-2509816] NUDT16 hydrolyses IDP to IMP - Rattus norvegicus [Reaction:R-MMU-2509816] NUDT16 hydrolyses IDP to IMP - Mus musculus
output	[SimpleEntity:R-ALL-9668967] H+ [nucleoplasm] [SimpleEntity:R-ALL-2509792] IMP [nucleoplasm] [SimpleEntity:R-ALL-113550] Pi [nucleoplasm]
regulatedBy	[Requirement:R-HSA-2509822] Requirement by 'Mg2+ [nucleoplasm]'
regulationReference	[RegulationReference:9641681] Requirement by 'Mg2+ [nucleoplasm]' NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2509804] Ito, Riyoko, 2012-10-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2509816
summation	[Summation:2509803] NUDT16 dimer catalyzes the reaction of IDP and water to form...
updateTrackers	[UpdateTracker:9776078] Update Tracker - [Reaction:2509816] NUDT16 hydrolyses IDP to IMP - v78:[addOutput]

Referrals

(updatedInstance)	[UpdateTracker:9776078] Update Tracker - [Reaction:2509816] NUDT16 hydrolyses IDP to IMP - v78:[addOutput]
(hasEvent)	[Pathway:R-HSA-2393930] Phosphate bond hydrolysis by NUDT proteins