Collagen type II degradation by MMP15

Stable Identifier
R-HSA-2473594
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Collagen type II degradation by MMP15
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The membrane-type MMP MMP15 (MT2-MMP) is a fibrillar collagenase. MMP15 is able to degrade collagen type I (Morrison & Overall 2006) and believed able to degrade types II and III (Somerville et al. 2003).

Literature References
Participants
Input
Output
Participates
as an event of
Catalyst Activity

metalloendopeptidase activity of MMP15 [plasma membrane]

Physical Entity
MMP15 [plasma membrane] (Homo sapiens)
Activity
metalloendopeptidase activity (GO:0004222)
Orthologous Events
Collagen type II degradation by MMP15 (Bos taurus)
Collagen type II degradation by MMP15 (Canis familiaris)
Collagen type II degradation by MMP15 (Danio rerio)
Collagen type II degradation by MMP15 (Gallus gallus)
Collagen type II degradation by MMP15 (Mus musculus)
Collagen type II degradation by MMP15 (Rattus norvegicus)
Collagen type II degradation by MMP15 (Sus scrofa)
Collagen type II degradation by MMP15 (Xenopus tropicalis)
Authored
Jupe, S  (2011-07-12)
Reviewed
Sorsa, T  (2012-10-08)
Created
Jupe, S  (2012-09-24)
Cite Us!