Reactome | Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2

Schema > Reaction > Entries

Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 Show undefined attributes

catalystActivity	[CatalystActivity:11093048] N-acetyltransferase activity of ESCO [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm [Compartment:81347] chromosome, centromeric region
created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11093062
displayName	Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2
eventOf	[Pathway:R-SCE-2468052] Establishment of Sister Chromatid Cohesion - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-2473152] Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113560] Ac-CoA [nucleoplasm] [Complex:R-SCE-2545177] Cohesin:PDS5:WAPAL:Centromere [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2
output	[Complex:R-SCE-2473149] Ac-Cohesin:PDS5:WAPAL:Centromere [nucleoplasm] 2 × [SimpleEntity:R-ALL-2485002] CoA-SH [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-2473152
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-2468052] Establishment of Sister Chromatid Cohesion
(inferredTo)	[Reaction:R-HSA-2473152] Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2

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