Reactome | Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2

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Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 Show undefined attributes

authored	[InstanceEdit:2500295] Orlic-Milacic, M, 2012-10-02
category	transition
compartment	[Compartment:1598585] chromosome [Compartment:7660] nucleoplasm
created	[InstanceEdit:2470937] Orlic-Milacic, M, 2012-09-20
dbId	2470935
displayName	Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2
edited	[InstanceEdit:2555380] Matthews, L, 2012-10-05 [InstanceEdit:2555378] Gillespie, ME, 2012-10-05
eventOf	[Pathway:R-HSA-2470946] Cohesin Loading onto Chromatin - Homo sapiens
followingEvent	[Reaction:R-HSA-2468039] Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 - Homo sapiens
input	[DefinedSet:R-ALL-2537690] Chromatin [chromosome] 2 × [Complex:R-HSA-2468042] Cohesin:PDS5:WAPAL [nucleoplasm] 2 × [Complex:R-HSA-2470930] NIPBL:MAU2 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2470251] Wapl controls the dynamic association of cohesin with chromatin [LiteratureReference:2470942] Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression
maxDepth	1
modified	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name	Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2
orthologousEvent	[Reaction:R-SPO-2470935] Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 - Schizosaccharomyces pombe [Reaction:R-DDI-2470935] Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 - Dictyostelium discoideum [Reaction:R-CEL-2470935] Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 - Caenorhabditis elegans [Reaction:R-DME-2470935] Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 - Drosophila melanogaster [Reaction:R-GGA-2470935] Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 - Gallus gallus [Reaction:R-SSC-2470935] Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 - Sus scrofa [Reaction:R-BTA-2470935] Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 - Bos taurus [Reaction:R-CFA-2470935] Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 - Canis familiaris [Reaction:R-RNO-2470935] Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 - Rattus norvegicus [Reaction:R-MMU-2470935] Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 - Mus musculus
output	[DefinedSet:R-HSA-2537688] Cohesin:PDS5:WAPAL:NIPBL:MAU2:Chromatin [nucleoplasm]
precedingEvent	[Reaction:R-HSA-2468040] Cohesin binds PDS5 and WAPAL - Homo sapiens
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2550413] Zhang, Nenggang, 2012-10-22 [InstanceEdit:3110247] Watanabe, Yoshinori, 2012-11-20 [InstanceEdit:3110251] Tanno, Yuji, 2012-11-20
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2470935
summation	[Summation:2470938] Cohesin, in complex with WAPAL and PDS5 (PDS5A or PDS5B) bin...

Referrals

(hasEvent)	[Pathway:R-HSA-2470946] Cohesin Loading onto Chromatin
(precedingEvent)	[Reaction:R-HSA-2468039] Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2