Reactome | Cohesin binds PDS5 and WAPAL

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Cohesin binds PDS5 and WAPAL Show undefined attributes

authored	[InstanceEdit:2500295] Orlic-Milacic, M, 2012-10-02
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:2468054] Orlic-Milacic, M, 2012-09-13
dbId	2468040
displayName	Cohesin binds PDS5 and WAPAL
edited	[InstanceEdit:2555380] Matthews, L, 2012-10-05 [InstanceEdit:2555378] Gillespie, ME, 2012-10-05
eventOf	[Pathway:R-HSA-2470946] Cohesin Loading onto Chromatin - Homo sapiens
followingEvent	[Reaction:R-HSA-2470935] Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 - Homo sapiens
input	[Complex:R-HSA-1641505] Cohesin Complex [nucleoplasm] [DefinedSet:R-HSA-2468044] PDS5 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-2466355] WAPAL [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2470265] Releasing cohesin from chromosome arms in early mitosis: opposing actions of Wapl-Pds5 and Sgo1 [LiteratureReference:2470251] Wapl controls the dynamic association of cohesin with chromatin [LiteratureReference:2470256] Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase
maxDepth	1
modified	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name	Cohesin binds PDS5 and WAPAL
orthologousEvent	[Reaction:R-SPO-2468040] Cohesin binds PDS5 and WAPAL - Schizosaccharomyces pombe [Reaction:R-CEL-2468040] Cohesin binds PDS5 and WAPAL - Caenorhabditis elegans [Reaction:R-DME-2468040] Cohesin binds PDS5 and WAPAL - Drosophila melanogaster [Reaction:R-GGA-2468040] Cohesin binds PDS5 and WAPAL - Gallus gallus [Reaction:R-DRE-2468040] Cohesin binds PDS5 and WAPAL - Danio rerio [Reaction:R-SSC-2468040] Cohesin binds PDS5 and WAPAL - Sus scrofa [Reaction:R-BTA-2468040] Cohesin binds PDS5 and WAPAL - Bos taurus [Reaction:R-CFA-2468040] Cohesin binds PDS5 and WAPAL - Canis familiaris [Reaction:R-RNO-2468040] Cohesin binds PDS5 and WAPAL - Rattus norvegicus [Reaction:R-MMU-2468040] Cohesin binds PDS5 and WAPAL - Mus musculus
output	[Complex:R-HSA-2468042] Cohesin:PDS5:WAPAL [nucleoplasm]
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2550413] Zhang, Nenggang, 2012-10-22 [InstanceEdit:3110247] Watanabe, Yoshinori, 2012-11-20 [InstanceEdit:3110251] Tanno, Yuji, 2012-11-20
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2468040
summation	[Summation:2470255] WAPAL (WAPL) and PDS5 proteins (PDS5A and/or PDS5B) are asso...

Referrals

(hasEvent)	[Pathway:R-HSA-2470946] Cohesin Loading onto Chromatin
(precedingEvent)	[Reaction:R-HSA-2470935] Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2