Cohesin binds PDS5 and WAPAL

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

WAPAL (WAPL) and PDS5 proteins (PDS5A and/or PDS5B) are associated with cohesin throughout most of the cell cycle (Kueng et al. 2006, Gandhi et al. 2006). FGF motifs present in the N-terminal region of WAPAL participate in WAPAL binding to PDS5 and cohesin subunits RAD21, STAG1 (SA1) and STAG2 (SA2) (Shintomi and Hirano 2009).

Literature References
PubMed ID Title Journal Year
19696148 Releasing cohesin from chromosome arms in early mitosis: opposing actions of Wapl-Pds5 and Sgo1

Shintomi, K, Hirano, T

Genes Dev. 2009
17113138 Wapl controls the dynamic association of cohesin with chromatin

Kueng, S, Hegemann, B, Peters, BH, Lipp, JJ, Schleiffer, A, Mechtler, K, Peters, JM

Cell 2006
17112726 Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase

Gandhi, R, Gillespie, PJ, Hirano, T

Curr. Biol. 2006
Participant Of
Orthologous Events
Cite Us!