Cohesin binds PDS5 and WAPAL

Stable Identifier
R-HSA-2468040
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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General
SVG |   | PPTX  | SBGN
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WAPAL (WAPL) and PDS5 proteins (PDS5A and/or PDS5B) are associated with cohesin throughout most of the cell cycle (Kueng et al. 2006, Gandhi et al. 2006). FGF motifs present in the N-terminal region of WAPAL participate in WAPAL binding to PDS5 and cohesin subunits RAD21, STAG1 (SA1) and STAG2 (SA2) (Shintomi and Hirano 2009).

Literature References
PubMed ID Title Journal Year
19696148 Releasing cohesin from chromosome arms in early mitosis: opposing actions of Wapl-Pds5 and Sgo1

Shintomi, K, Hirano, T

Genes Dev. 2009
17113138 Wapl controls the dynamic association of cohesin with chromatin

Kueng, S, Hegemann, B, Peters, BH, Lipp, JJ, Schleiffer, A, Mechtler, K, Peters, JM

Cell 2006
17112726 Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase

Gandhi, R, Gillespie, PJ, Hirano, T

Curr. Biol. 2006
Participants
Participant Of
Orthologous Events
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Created