Reactome | Cohesin binds PDS5 and WAPAL

Cohesin binds PDS5 and WAPAL

Stable Identifier

R-HSA-2468040

Type

Reaction

Species

Homo sapiens

Compartment

nucleoplasm

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WAPAL (WAPL) and PDS5 proteins (PDS5A and/or PDS5B) are associated with cohesin throughout most of the cell cycle (Kueng et al. 2006, Gandhi et al. 2006). FGF motifs present in the N-terminal region of WAPAL participate in WAPAL binding to PDS5 and cohesin subunits RAD21, STAG1 (SA1) and STAG2 (SA2) (Shintomi and Hirano 2009).

Literature References

PubMed ID	Title	Journal	Year
17113138	Wapl controls the dynamic association of cohesin with chromatin Peters, BH, Hegemann, B, Peters, JM, Mechtler, K, Schleiffer, A, Kueng, S, Lipp, JJ	Cell	2006
19696148	Releasing cohesin from chromosome arms in early mitosis: opposing actions of Wapl-Pds5 and Sgo1 Shintomi, K, Hirano, T	Genes Dev.	2009
17112726	Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase Gandhi, R, Hirano, T, Gillespie, PJ	Curr. Biol.	2006