Reactome | IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2

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IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 Show undefined attributes

authored	[InstanceEdit:2428925] May, B, 2012-08-06
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:2428929] May, B, 2012-08-08
dbId	2428922
displayName	IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2
edited	[InstanceEdit:2428925] May, B, 2012-08-06
eventOf	[Pathway:R-HSA-2428928] IRS-related events triggered by IGF1R - Homo sapiens
followingEvent	[Reaction:R-HSA-2428926] IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 - Homo sapiens
input	[Complex:R-HSA-2404189] IGF1,2:p-3Y-IGF1R [plasma membrane] [EntityWithAccessionedSequence:R-HSA-57528] IRS2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2428918] Insulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signaling [LiteratureReference:2453733] Interaction of insulin receptor substrate-2 (IRS-2) with the insulin and insulin-like growth factor I receptors. Evidence for two distinct phosphotyrosine-dependent interaction domains within IRS-2
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2
orthologousEvent	[Reaction:R-GGA-2428922] IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 - Gallus gallus [Reaction:R-XTR-2428922] IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 - Xenopus tropicalis [Reaction:R-SSC-2428922] IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 - Sus scrofa [Reaction:R-BTA-2428922] IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 - Bos taurus [Reaction:R-CFA-2428922] IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 - Canis familiaris [Reaction:R-RNO-2428922] IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 - Rattus norvegicus [Reaction:R-MMU-2428922] IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 - Mus musculus
output	[Complex:R-HSA-2428931] IGF1,2:p-IGF1R:IRS2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-2404199] IGF1,2:IGF1R autophosphorylates - Homo sapiens
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2566980] Holzenberger, Martin, 2012-11-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2428922
summation	[Summation:2454031] IRS2 binds the NPEY-juxtamembrane motif of phosphorylated IG...

Referrals

(hasEvent)	[Pathway:R-HSA-2428928] IRS-related events triggered by IGF1R
(precedingEvent)	[Reaction:R-HSA-2428926] IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4