IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2

Stable Identifier
R-HSA-2428922
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2
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IRS2 binds the NPEY-juxtamembrane motif of phosphorylated IGF1R (He et al. 1996, Kim et al. 1998). IRS2 is cytosolic while IRS1 and IRS4 are located in the plasma membrane.

Literature References
PubMed ID Title Journal Year
8662806 Interaction of insulin receptor substrate-2 (IRS-2) with the insulin and insulin-like growth factor I receptors. Evidence for two distinct phosphotyrosine-dependent interaction domains within IRS-2

He, W, Craparo, A, Zhu, Y, O'Neill, TJ, Wang, LM, Pierce, JH, Gustafson, TA

J. Biol. Chem. 1996
9852124 Insulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signaling

Kim, B, Cheng, HL, Margolis, B, Feldman, EL

J. Biol. Chem. 1998
Participants
Input
Output
Participant Of
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Orthologous Events
IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Canis familiaris)
IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Danio rerio)
IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Mus musculus)
IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Rattus norvegicus)
IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Xenopus tropicalis)
Authored
May, B  (2012-08-07)
Reviewed
Holzenberger, M  (2012-11-10)
Created
May, B  (2012-08-09)
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