Reactome | IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1

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IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 Show undefined attributes

authored	[InstanceEdit:2404196] May, B, 2012-07-07
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2404198] May, B, 2012-07-16
dbId	2404195
displayName	IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1
edited	[InstanceEdit:2404196] May, B, 2012-07-07
eventOf	[Pathway:R-HSA-2428933] SHC-related events triggered by IGF1R - Homo sapiens
followingEvent	[Reaction:R-HSA-2404193] IGF1R phosphorylates SHC1 - Homo sapiens
input	[Complex:R-HSA-2404189] IGF1,2:p-3Y-IGF1R [plasma membrane] [DefinedSet:R-HSA-2404191] SHC1 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2445115] Evidence for a differential interaction of SHC and the insulin receptor substrate-1 (IRS-1) with the insulin-like growth factor-I (IGF-I) receptor in the yeast two-hybrid system [LiteratureReference:2424286] Involvement of Src-homology/collagen (SHC) proteins in signaling through the insulin receptor and the insulin-like-growth-factor-I-receptor
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1
orthologousEvent	[Reaction:R-GGA-2404195] IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 - Gallus gallus [Reaction:R-SSC-2404195] IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 - Sus scrofa [Reaction:R-BTA-2404195] IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 - Bos taurus [Reaction:R-CFA-2404195] IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 - Canis familiaris [Reaction:R-RNO-2404195] IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 - Rattus norvegicus [Reaction:R-MMU-2404195] IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 - Mus musculus
output	[Complex:R-HSA-2404185] IGF1,2:p-3Y-IGF1R:SHC1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-2404199] IGF1,2:IGF1R autophosphorylates - Homo sapiens
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2566980] Holzenberger, Martin, 2012-11-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2404195
summation	[Summation:2454024] SHC binds the NPEY-juxtamembrane motif of the phosphorylated...
updateTrackers	[UpdateTracker:9784621] Update Tracker - [Reaction:2404195] IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 - v53:[add_removeInput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9784621] Update Tracker - [Reaction:2404195] IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 - v53:[add_removeInput, modifyText]
(hasEvent)	[Pathway:R-HSA-2428933] SHC-related events triggered by IGF1R
(precedingEvent)	[Reaction:R-HSA-2404193] IGF1R phosphorylates SHC1