Reactome | PIK3R1 G376R [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2399719] Orlic-Milacic, M, 2012-07-12
crossReference	[DatabaseIdentifier:12020790] Mondo:0018177 [DatabaseIdentifier:2399720] COSMIC:COSV57123316 [DatabaseIdentifier:2399721] COSMIC:COSM132923
dbId	2399717
disease	[Disease:1500689] cancer [Disease:1247632] glioblastoma [Disease:2317358] endometrial cancer
displayName	PIK3R1 G376R [plasma membrane]
endCoordinate	724
hasModifiedResidue	[ReplacedResidue:2399718] glycine 376 replaced with L-arginine
inDisease	true
literatureReference	[LiteratureReference:2399685] Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha
maxDepth	1
memberOf	[CandidateSet:R-HSA-2399722] PIK3R1 nSH2 domain mutants [plasma membrane] - Homo sapiens
modified	[InstanceEdit:5624358] Jupe, Steve, 2014-09-26
name	PIK3R1 G376R PIK3R1 Gly376Arg
referenceEntity	[ReferenceGeneProduct:uniprot:P27986] UniProt:P27986 PIK3R1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-2399717
startCoordinate	1
summation	[Summation:2399716] The substitution of glycine residue with arginine at positio...
updateTrackers	[UpdateTracker:9888045] Update Tracker - [EntityWithAccessionedSequence:2399717] PIK3R1 G376R [plasma membrane] - v46:[modifyName]

(updatedInstance)	[UpdateTracker:9888045] Update Tracker - [EntityWithAccessionedSequence:2399717] PIK3R1 G376R [plasma membrane] - v46:[modifyName]
(hasMember)	[CandidateSet:R-HSA-2399722] PIK3R1 nSH2 domain mutants [plasma membrane]

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