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created	[InstanceEdit:2399719] Orlic-Milacic, M, 2012-07-12
dbId	2399716
displayName	The substitution of glycine residue with arginine at positio...
literatureReference	[LiteratureReference:2399685] Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha
schemaClass	Summation
text	The substitution of glycine residue with arginine at position 376 in the nSH2 domain of PIK3R1 relieves the inhibitory effect on the PI3K catalytic subunit, PIK3CA, resulting in constitutive activity of PI3K complex that contains PIK3R1 G376R mutant (Sun et al. 2010).

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