Reactome | PTEN R173H [cytosol]

Schema > EntityWithAccessionedSequence > Entries

PTEN R173H [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2317472] Orlic-Milacic, M, 2012-06-11
crossReference	[DatabaseIdentifier:12021108] Mondo:0005499 [DatabaseIdentifier:2317471] COSMIC:COSV64288961
dbId	2317473
disease	[Disease:1996312] brain glioma [Disease:2317358] endometrial cancer [Disease:1500575] ovarian cancer [Disease:1500689] cancer
displayName	PTEN R173H [cytosol]
endCoordinate	403
hasModifiedResidue	[ReplacedResidue:2317470] L-arginine 173 replaced with L-histidine
inDisease	true
literatureReference	[LiteratureReference:1889775] Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay [LiteratureReference:2317505] Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association
maxDepth	1
memberOf	[CandidateSet:R-HSA-2317372] PTEN Phosphatase Domain Missense Mutants [cytosol] - Homo sapiens
modified	[InstanceEdit:9967512] D'Eustachio, Peter, 2025-09-30
name	PTEN R173H PTEN Arg173His
referenceEntity	[ReferenceGeneProduct:uniprot:P60484] UniProt:P60484 PTEN
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-2317473
startCoordinate	2
summation	[Summation:2317487] PTEN missense mutation that results in the substitution of a...
updateTrackers	[UpdateTracker:9971969] Update Tracker - [EntityWithAccessionedSequence:2317473] PTEN R173H [cytosol] - v95:[modifyStartCoordinate] [UpdateTracker:9888495] Update Tracker - [EntityWithAccessionedSequence:2317473] PTEN R173H [cytosol] - v46:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9971969] Update Tracker - [EntityWithAccessionedSequence:2317473] PTEN R173H [cytosol] - v95:[modifyStartCoordinate] [UpdateTracker:9888495] Update Tracker - [EntityWithAccessionedSequence:2317473] PTEN R173H [cytosol] - v46:[modifyName]
(hasMember)	[CandidateSet:R-HSA-2317372] PTEN Phosphatase Domain Missense Mutants [cytosol]