Reactome | Activator:PI3K [plasma membrane]

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Activator:PI3K [plasma membrane] Show undefined attributes

catalystActivities	[CatalystActivity:2316433] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of Activator:PI3K [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2316430] Orlic-Milacic, M, 2012-06-09
dbId	2316432
displayName	Activator:PI3K [plasma membrane]
hasMember	[Complex:R-HSA-205177] PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] - Homo sapiens [Complex:R-HSA-388783] CD28:PI3K [plasma membrane] - Homo sapiens [Complex:R-HSA-186789] PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] - Homo sapiens [Complex:R-HSA-202283] PI3K bound to TRAT [plasma membrane] - Homo sapiens [Complex:R-HSA-198344] Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] - Homo sapiens [Complex:R-HSA-1306961] EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] - Homo sapiens [Complex:R-HSA-1250508] NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] - Homo sapiens [Complex:R-HSA-1306974] NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] - Homo sapiens [Complex:R-HSA-1250373] PI3K:p-ERBB4cyt1 [plasma membrane] - Homo sapiens [Complex:R-HSA-179791] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] - Homo sapiens [Complex:R-HSA-2076233] CD19 Signalosome [plasma membrane] - Homo sapiens [Complex:R-HSA-2045909] BCAP Signalosome [plasma membrane] - Homo sapiens [Complex:R-HSA-388785] ICOS:PI3K [plasma membrane] - Homo sapiens [Complex:R-HSA-5654205] Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] - Homo sapiens [Complex:R-HSA-5654190] Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] - Homo sapiens [Complex:R-HSA-5654195] Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] - Homo sapiens [Complex:R-HSA-5654187] Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] - Homo sapiens [Complex:R-HSA-5654188] Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] - Homo sapiens [Complex:R-HSA-5654192] Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] - Homo sapiens [Complex:R-HSA-5654197] Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] - Homo sapiens [Complex:R-HSA-8851953] HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] - Homo sapiens [Complex:R-HSA-9021654] ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] - Homo sapiens [Complex:R-HSA-114540] RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] - Homo sapiens [Complex:R-HSA-9698169] Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] - Homo sapiens [Complex:R-HSA-9028508] BDNF,NTF4:p-5Y-NTRK2:GRB2:GAB1:PIK3CA:PIK3R1 [plasma membrane] - Homo sapiens [Complex:R-HSA-9603404] NTF3:p-5Y-NTRK3 homodimer:PI3K [plasma membrane] - Homo sapiens
inDisease	false
inferredTo	[DefinedSet:R-MMU-2316432] Activator:PI3K [plasma membrane] - Mus musculus [DefinedSet:R-RNO-2316432] Activator:PI3K [plasma membrane] - Rattus norvegicus [DefinedSet:R-CFA-2316432] Activator:PI3K [plasma membrane] - Canis familiaris [DefinedSet:R-BTA-2316432] Activator:PI3K [plasma membrane] - Bos taurus [DefinedSet:R-SSC-2316432] Activator:PI3K [plasma membrane] - Sus scrofa [DefinedSet:R-DRE-2316432] Activator:PI3K [plasma membrane] - Danio rerio [DefinedSet:R-XTR-2316432] Activator:PI3K [plasma membrane] - Xenopus tropicalis [DefinedSet:R-GGA-2316432] Activator:PI3K [plasma membrane] - Gallus gallus [DefinedSet:R-DME-2316432] Activator:PI3K [plasma membrane] - Drosophila melanogaster [DefinedSet:R-CEL-2316432] Activator:PI3K [plasma membrane] - Caenorhabditis elegans
maxDepth	12
memberOf	[CandidateSet:R-HSA-2400011] PI3K mutants,Activator:PI3K [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9865756] Orlic-Milacic, Marija, 2024-03-18
name	Activator:PI3K
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-2316432
updateTrackers	[UpdateTracker:9900333] Update Tracker - [DefinedSet:2316432] Activator:PI3K [plasma membrane] - v68:[updateContainedMemberOrCandidate] [UpdateTracker:9901963] Update Tracker - [DefinedSet:2316432] Activator:PI3K [plasma membrane] - v76:[updateContainedMemberOrCandidate] [UpdateTracker:9899427] Update Tracker - [DefinedSet:2316432] Activator:PI3K [plasma membrane] - v66:[addHasMember] [UpdateTracker:9894990] Update Tracker - [DefinedSet:2316432] Activator:PI3K [plasma membrane] - v58:[addHasMember] [UpdateTracker:9877626] Update Tracker - [DefinedSet:2316432] Activator:PI3K [plasma membrane] - v44:[updateContainedMemberOrCandidate] [UpdateTracker:9898468] Update Tracker - [DefinedSet:2316432] Activator:PI3K [plasma membrane] - v64:[updateContainedMemberOrCandidate] [UpdateTracker:9899935] Update Tracker - [DefinedSet:2316432] Activator:PI3K [plasma membrane] - v67:[updateContainedMemberOrCandidate] [UpdateTracker:9898098] Update Tracker - [DefinedSet:2316432] Activator:PI3K [plasma membrane] - v63:[addHasMember, updateContainedMemberOrCandidate] [UpdateTracker:9901760] Update Tracker - [DefinedSet:2316432] Activator:PI3K [plasma membrane] - v75:[addHasMember] [UpdateTracker:9890347] Update Tracker - [DefinedSet:2316432] Activator:PI3K [plasma membrane] - v52:[add_removeHasMember] [UpdateTracker:9928547] Update Tracker - [DefinedSet:2316432] Activator:PI3K [plasma membrane] - v91:[updateContainedMemberOrCandidate] [UpdateTracker:9894760] Update Tracker - [DefinedSet:2316432] Activator:PI3K [plasma membrane] - v57:[updateContainedMemberOrCandidate] [UpdateTracker:9900786] Update Tracker - [DefinedSet:2316432] Activator:PI3K [plasma membrane] - v70:[updateContainedMemberOrCandidate] [UpdateTracker:9895317] Update Tracker - [DefinedSet:2316432] Activator:PI3K [plasma membrane] - v59:[updateContainedMemberOrCandidate] [UpdateTracker:9893572] Update Tracker - [DefinedSet:2316432] Activator:PI3K [plasma membrane] - v56:[updateContainedMemberOrCandidate] [UpdateTracker:9899244] Update Tracker - [DefinedSet:2316432] Activator:PI3K [plasma membrane] - v65:[updateContainedMemberOrCandidate] [UpdateTracker:9901090] Update Tracker - [DefinedSet:2316432] Activator:PI3K [plasma membrane] - v72:[updateContainedMemberOrCandidate]

Referrals

(hasMember)	[CandidateSet:R-HSA-2400011] PI3K mutants,Activator:PI3K [plasma membrane]
(physicalEntity)	[CatalystActivity:2316433] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of Activator:PI3K [plasma membrane]
(normalEntity)	[EntityFunctionalStatus:2632525] gain_of_function of PI3K mutants [plasma membrane]
(updatedInstance)	[UpdateTracker:9900333] Update Tracker - [DefinedSet:2316432] Activator:PI3K [plasma membrane] - v68:[updateContainedMemberOrCandidate] [UpdateTracker:9901963] Update Tracker - [DefinedSet:2316432] Activator:PI3K [plasma membrane] - v76:[updateContainedMemberOrCandidate] [UpdateTracker:9899427] Update Tracker - [DefinedSet:2316432] Activator:PI3K [plasma membrane] - v66:[addHasMember] [UpdateTracker:9894990] Update Tracker - [DefinedSet:2316432] Activator:PI3K [plasma membrane] - v58:[addHasMember] [UpdateTracker:9877626] Update Tracker - [DefinedSet:2316432] Activator:PI3K [plasma membrane] - v44:[updateContainedMemberOrCandidate] [UpdateTracker:9898468] Update Tracker - [DefinedSet:2316432] Activator:PI3K [plasma membrane] - v64:[updateContainedMemberOrCandidate] [UpdateTracker:9899935] Update Tracker - [DefinedSet:2316432] Activator:PI3K [plasma membrane] - v67:[updateContainedMemberOrCandidate] [UpdateTracker:9898098] Update Tracker - [DefinedSet:2316432] Activator:PI3K [plasma membrane] - v63:[addHasMember, updateContainedMemberOrCandidate] [UpdateTracker:9901760] Update Tracker - [DefinedSet:2316432] Activator:PI3K [plasma membrane] - v75:[addHasMember] [UpdateTracker:9890347] Update Tracker - [DefinedSet:2316432] Activator:PI3K [plasma membrane] - v52:[add_removeHasMember] [UpdateTracker:9928547] Update Tracker - [DefinedSet:2316432] Activator:PI3K [plasma membrane] - v91:[updateContainedMemberOrCandidate] [UpdateTracker:9894760] Update Tracker - [DefinedSet:2316432] Activator:PI3K [plasma membrane] - v57:[updateContainedMemberOrCandidate] [UpdateTracker:9900786] Update Tracker - [DefinedSet:2316432] Activator:PI3K [plasma membrane] - v70:[updateContainedMemberOrCandidate] [UpdateTracker:9895317] Update Tracker - [DefinedSet:2316432] Activator:PI3K [plasma membrane] - v59:[updateContainedMemberOrCandidate] [UpdateTracker:9893572] Update Tracker - [DefinedSet:2316432] Activator:PI3K [plasma membrane] - v56:[updateContainedMemberOrCandidate] [UpdateTracker:9899244] Update Tracker - [DefinedSet:2316432] Activator:PI3K [plasma membrane] - v65:[updateContainedMemberOrCandidate] [UpdateTracker:9901090] Update Tracker - [DefinedSet:2316432] Activator:PI3K [plasma membrane] - v72:[updateContainedMemberOrCandidate]

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