Reactome | Arachidonate is oxidised to PGG2 by PTGS2

Schema > Reaction > Entries

Arachidonate is oxidised to PGG2 by PTGS2 Show undefined attributes

authored	[InstanceEdit:378946] Jassal, Bijay, 2008-10-01
catalystActivity	[CatalystActivity:2309772] prostaglandin-endoperoxide synthase activity of PTGS2 dimer [endoplasmic reticulum membrane]
catalystActivityReference	[CatalystActivityReference:9915554] prostaglandin-endoperoxide synthase activity of PTGS2 dimer [endoplasmic reticulum membrane] Prostaglandin H synthase-2-catalyzed oxygenation of 2-arachidonoylglycerol is more sensitive to peroxide tone than oxygenation of arachidonic acid
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:2309789] D'Eustachio, P, 2012-06-05
crossReference	[DatabaseIdentifier:12668317] RHEA:42597 [DatabaseIdentifier:9915546] RHEA:42597
dbId	2309787
displayName	Arachidonate is oxidised to PGG2 by PTGS2
edited	[InstanceEdit:351780] Jassal, B, 2008-05-28 09:06:10 [InstanceEdit:350358] Jassal, Bijay, 2008-05-19
eventOf	[Pathway:R-HSA-2162123] Synthesis of Prostaglandins (PG) and Thromboxanes (TX) - Homo sapiens
followingEvent	[Reaction:R-HSA-2309773] PGG2 is reduced to PGH2 by PTGS2 - Homo sapiens
input	[SimpleEntity:R-ALL-140356] AA [endoplasmic reticulum lumen] 2 × [SimpleEntity:R-ALL-113534] O2 [endoplasmic reticulum lumen]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:140560] Isolation and structure of two prostaglandin endoperoxides that cause platelet aggregation [LiteratureReference:140564] Isolation and properties of intermediates in prostaglandin biosynthesis
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Arachidonate is oxidised to PGG2 by PTGS2 (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 => prostaglandin G2 Arachidonate oxidised to PGG2
orthologousEvent	[Reaction:R-GGA-2309787] Arachidonate is oxidised to PGG2 by PTGS2 - Gallus gallus [Reaction:R-XTR-2309787] Arachidonate is oxidised to PGG2 by PTGS2 - Xenopus tropicalis [Reaction:R-DRE-2309787] Arachidonate is oxidised to PGG2 by PTGS2 - Danio rerio [Reaction:R-SSC-2309787] Arachidonate is oxidised to PGG2 by PTGS2 - Sus scrofa [Reaction:R-BTA-2309787] Arachidonate is oxidised to PGG2 by PTGS2 - Bos taurus [Reaction:R-CFA-2309787] Arachidonate is oxidised to PGG2 by PTGS2 - Canis familiaris [Reaction:R-RNO-2309787] Arachidonate is oxidised to PGG2 by PTGS2 - Rattus norvegicus [Reaction:R-MMU-2309787] Arachidonate is oxidised to PGG2 by PTGS2 - Mus musculus
output	[SimpleEntity:R-ALL-140357] PGG2 [endoplasmic reticulum lumen]
precedingEvent	[Reaction:R-HSA-111883] PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine - Homo sapiens
releaseDate	2008-06-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2569042] Rush, MG, 2012-11-10
revised	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2309787
summation	[Summation:2309785] Prostaglandin G/H synthase PTGS2 exhibits a dual catalytic a...
updateTrackers	[UpdateTracker:9919451] Update Tracker - [Reaction:2309787] Arachidonate is oxidised to PGG2 by PTGS2 - v90:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9919451] Update Tracker - [Reaction:2309787] Arachidonate is oxidised to PGG2 by PTGS2 - v90:[modifyText]
(hasEvent)	[Pathway:R-HSA-2162123] Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
(precedingEvent)	[Reaction:R-HSA-2309773] PGG2 is reduced to PGH2 by PTGS2