Reactome | Arachidonate is oxidised to PGG2 by PTGS2

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Arachidonate is oxidised to PGG2 by PTGS2 Show undefined attributes

catalystActivity	[CatalystActivity:10781108] prostaglandin-endoperoxide synthase activity of PTGS2 dimer [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10781110
displayName	Arachidonate is oxidised to PGG2 by PTGS2
eventOf	[Pathway:R-GGA-2162123] Synthesis of Prostaglandins (PG) and Thromboxanes (TX) - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-2309773] PGG2 is reduced to PGH2 by PTGS2 - Gallus gallus
inferredFrom	[Reaction:R-HSA-2309787] Arachidonate is oxidised to PGG2 by PTGS2 - Homo sapiens
input	[SimpleEntity:R-ALL-140356] AA [endoplasmic reticulum lumen] 2 × [SimpleEntity:R-ALL-113534] O2 [endoplasmic reticulum lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	Arachidonate is oxidised to PGG2 by PTGS2 (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 => prostaglandin G2 Arachidonate oxidised to PGG2
output	[SimpleEntity:R-ALL-140357] PGG2 [endoplasmic reticulum lumen]
precedingEvent	[Reaction:R-GGA-111883] PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-2309787
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-2162123] Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
(precedingEvent)	[Reaction:R-GGA-2309773] PGG2 is reduced to PGH2 by PTGS2
(inferredTo)	[Reaction:R-HSA-2309787] Arachidonate is oxidised to PGG2 by PTGS2

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