Arachidonic acid is oxidised to PGG2 by PTGS2

Stable Identifier
R-HSA-2309787
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Arachidonic acid oxidised to PGG2
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Prostaglandin G/H synthase PTGS2 exhibits a dual catalytic activity, a cyclooxygenase and a peroxidase. The cyclooxygenase function catalyzes the initial conversion of arachidonic acid to an intermediate, prostaglandin G2 (PGG2) (Hamberg et al. 1974, Nugteren 1973).

Literature References
PubMed ID Title Journal Year
4521806 Isolation and structure of two prostaglandin endoperoxides that cause platelet aggregation

Hamberg, M, Svensson, J, Wakabayashi, T, Samuelsson, B

Proc Natl Acad Sci U S A 1974
4776443 Isolation and properties of intermediates in prostaglandin biosynthesis

Nugteren, DH, Hazelhof, E

Biochim Biophys Acta 1973
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
prostaglandin-endoperoxide synthase activity of PTGS2 dimer [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created