Reactome | Condensation of Prophase Chromosomes

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Condensation of Prophase Chromosomes Show undefined attributes

authored	[InstanceEdit:3301857] Orlic-Milacic, M, 2013-04-22 [InstanceEdit:3296380] Gallie, Brenda L, 2013-04-11
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:2299719] Orlic-Milacic, M, 2012-06-04
dbId	2299718
displayName	Condensation of Prophase Chromosomes
doi	10.3180/REACT_172744.1
edited	[InstanceEdit:3451184] Matthews, L, 2013-04-23
eventOf	[Pathway:R-HSA-68875] Mitotic Prophase - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:18551] mitotic chromosome condensation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-2301205] SETD8 monomethylates histone H4 - Homo sapiens [Reaction:R-HSA-2172678] PHF8 demethylates histone H4K20me1 - Homo sapiens [Reaction:R-HSA-2245218] CDK1 phosphorylates PHF8 - Homo sapiens [Reaction:R-HSA-2172666] RB1 binds condensin II - Homo sapiens [Reaction:R-HSA-2288097] Condensin II complex binds H4K20me1-containing nucleosomes - Homo sapiens [Reaction:R-HSA-2294600] CDK1 phosphorylates condensin II subunit NCAPD3 - Homo sapiens [Reaction:R-HSA-2294590] PLK1 binds phosphorylated condensin II complex - Homo sapiens [Reaction:R-HSA-2294580] PLK1 hyperphosphorylates Condensin II complex - Homo sapiens [BlackBoxEvent:R-HSA-2294574] Condensin II-mediated condensation of prophase chromosomes - Homo sapiens [Reaction:R-HSA-2429719] MCPH1 sequesters condensin II - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2017-06-22
literatureReference	[LiteratureReference:2172680] PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression [LiteratureReference:2172659] RBF1 promotes chromatin condensation through a conserved interaction with the Condensin II protein dCAP-D3 [LiteratureReference:2301208] Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression [LiteratureReference:2301217] Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes [LiteratureReference:2301212] PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin [LiteratureReference:2294599] The initial phase of chromosome condensation requires Cdk1-mediated phosphorylation of the CAP-D3 subunit of condensin II
maxDepth	2
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Condensation of Prophase Chromosomes
orthologousEvent	[Pathway:R-BTA-2299718] Condensation of Prophase Chromosomes - Bos taurus [Pathway:R-SCE-2299718] Condensation of Prophase Chromosomes - Saccharomyces cerevisiae [Pathway:R-SPO-2299718] Condensation of Prophase Chromosomes - Schizosaccharomyces pombe [Pathway:R-DDI-2299718] Condensation of Prophase Chromosomes - Dictyostelium discoideum [Pathway:R-CEL-2299718] Condensation of Prophase Chromosomes - Caenorhabditis elegans [Pathway:R-GGA-2299718] Condensation of Prophase Chromosomes - Gallus gallus [Pathway:R-XTR-2299718] Condensation of Prophase Chromosomes - Xenopus tropicalis [Pathway:R-DRE-2299718] Condensation of Prophase Chromosomes - Danio rerio [Pathway:R-SSC-2299718] Condensation of Prophase Chromosomes - Sus scrofa [Pathway:R-CFA-2299718] Condensation of Prophase Chromosomes - Canis familiaris [Pathway:R-RNO-2299718] Condensation of Prophase Chromosomes - Rattus norvegicus [Pathway:R-MMU-2299718] Condensation of Prophase Chromosomes - Mus musculus
releaseDate	2013-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5085845] Longworth, MS, 2013-10-14
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-2299718
summation	[Summation:2301227] In mitotic prophase, the action of the condensin II complex ...
updateTrackers	[UpdateTracker:9781083] Update Tracker - [Pathway:2299718] Condensation of Prophase Chromosomes - v61:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9781083] Update Tracker - [Pathway:2299718] Condensation of Prophase Chromosomes - v61:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-68875] Mitotic Prophase

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