Reactome | PLK1 phosphorylates GORASP1

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PLK1 phosphorylates GORASP1 Show undefined attributes

authored	[InstanceEdit:156701] Lee, KS, 2004-12-08 21:18:23
catalystActivity	[CatalystActivity:2214352] protein serine/threonine kinase activity of p-T216,S274,S373-GORASP1:p-S37-GOLGA2:p-RAB1:GTP:p-T210-PLK1 [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:70101] cytosol
created	[InstanceEdit:2214350] Orlic-Milacic, M, 2012-04-30
dbId	2214351
displayName	PLK1 phosphorylates GORASP1
edited	[InstanceEdit:162660] Gillespie, ME, 2005-04-04 01:40:57
eventOf	[Pathway:R-HSA-162658] Golgi Cisternae Pericentriolar Stack Reorganization - Homo sapiens
figure	[Figure:162989] /figures/polokinases_GRASP65.jpg
followingEvent	[BlackBoxEvent:R-HSA-2314566] GORASP1 phosphorylated by PLK1 and GORASP2 phosphorylated by MAPK3-3/MAPK1 are unable to promote Golgi cisternae stacking - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-2172193] p-T216,S274,S373-GORASP1:p-S37-GOLGA2:p-RAB1:GTP:p-T210-PLK1 [Golgi membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:162969] Plk1 docking to GRASP65 phosphorylated by Cdk1 suggests a mechanism for Golgi checkpoint signalling [LiteratureReference:2314408] Mitotic inhibition of GRASP65 organelle tethering involves Polo-like kinase 1 (PLK1) phosphorylation proximate to an internal PDZ ligand [LiteratureReference:162958] Polo-like kinase is required for the fragmentation of pericentriolar Golgi stacks during mitosis [LiteratureReference:2463812] A direct role for GRASP65 as a mitotically regulated Golgi stacking factor
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	PLK1 phosphorylates GORASP1 Activation of the Anaphase Promoting Complex (APC) by PLK1
orthologousEvent	[Reaction:R-BTA-2214351] PLK1 phosphorylates GORASP1 - Bos taurus [Reaction:R-PFA-2214351] PLK1 phosphorylates GORASP1 - Plasmodium falciparum [Reaction:R-SCE-2214351] PLK1 phosphorylates GORASP1 - Saccharomyces cerevisiae [Reaction:R-SPO-2214351] PLK1 phosphorylates GORASP1 - Schizosaccharomyces pombe [Reaction:R-DDI-2214351] PLK1 phosphorylates GORASP1 - Dictyostelium discoideum [Reaction:R-CEL-2214351] PLK1 phosphorylates GORASP1 - Caenorhabditis elegans [Reaction:R-DME-2214351] PLK1 phosphorylates GORASP1 - Drosophila melanogaster [Reaction:R-GGA-2214351] PLK1 phosphorylates GORASP1 - Gallus gallus [Reaction:R-XTR-2214351] PLK1 phosphorylates GORASP1 - Xenopus tropicalis [Reaction:R-DRE-2214351] PLK1 phosphorylates GORASP1 - Danio rerio [Reaction:R-SSC-2214351] PLK1 phosphorylates GORASP1 - Sus scrofa [Reaction:R-CFA-2214351] PLK1 phosphorylates GORASP1 - Canis familiaris [Reaction:R-RNO-2214351] PLK1 phosphorylates GORASP1 - Rattus norvegicus [Reaction:R-MMU-2214351] PLK1 phosphorylates GORASP1 - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-2314414] p-T216,S189,S274,S373-GORASP1:p-S37-GOLGA2:p-RAB1:GTP:p-T210-PLK1 [Golgi membrane]
precedingEvent	[Reaction:R-HSA-2172194] Recruitment of PLK1 to phosphorylated GORASP1 (GRASP65) - Homo sapiens
releaseDate	2005-04-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2463852] Wang, Yanzhuang, 2012-08-19 [InstanceEdit:2463846] Colanzi, Antonino, 2012-08-21 [InstanceEdit:2507813] Malhotra, Vivek, 2012-08-15
revised	[InstanceEdit:2424242] Orlic-Milacic, M, 2012-07-20
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2214351
summation	[Summation:2314560] CDK1-mediated phosphorylation of GORASP1 (GRASP65) enables G...
updateTrackers	[UpdateTracker:9788178] Update Tracker - [Reaction:2214351] PLK1 phosphorylates GORASP1 - v43:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9788178] Update Tracker - [Reaction:2214351] PLK1 phosphorylates GORASP1 - v43:[modifyText]
(hasEvent)	[Pathway:R-HSA-162658] Golgi Cisternae Pericentriolar Stack Reorganization
(precedingEvent)	[BlackBoxEvent:R-HSA-2314566] GORASP1 phosphorylated by PLK1 and GORASP2 phosphorylated by MAPK3-3/MAPK1 are unable to promote Golgi cisternae stacking

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