Platelet glycoprotein IV (CD36) binds ligands

Stable Identifier
Reaction [binding]
Homo sapiens
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CD36 (Platelet glycoprotein IV) binds oxidized LDL (Janabi et al. 2000, Endemann et al. 1993) through both the lipid and the protein moieties of LDL (Boullier et al. 2000), oxidized phospholipids (Podrez et al. 2002), long-chain fatty acids (inferred from rat and mouse, Abumrad et al. 1993, Laugerette et al. 2005), hexarelin (a hexapeptide member of the growth hormone-releasing peptide family) (inferred from rat and mouse, Bodart et al. 2002), betaglucan (Means et al. 2009), oxidized and native phosphatidylserine (Greenberg et al. 2006) and apoptotic cells (Ren et al. 1995; Fadok et al. 1998), lipopeptide from Staphylococcus aureus as well as lipoteichoic acid from Gram-positive bacteria, both in cooperation with TLR2 (inferred from mouse, Hoebe et al. 2005). As inferred from mouse, CD36 also binds phosphatidylinositol, and HDL.

Literature References
PubMed ID Title Journal Year
10734051 The binding of oxidized low density lipoprotein to mouse CD36 is mediated in part by oxidized phospholipids that are associated with both the lipid and protein moieties of the lipoprotein

Boullier, A, Gillotte, KL, Hörkkö, S, Green, SR, Friedman, P, Dennis, EA, Witztum, JL, Steinberg, D, Quehenberger, O

J Biol Chem 2000
7536797 CD36 gene transfer confers capacity for phagocytosis of cells undergoing apoptosis

Ren, Y, Silverstein, RL, Allen, J, Savill, J

J. Exp. Med. 1995
10772654 Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species

Podrez, EA, Febbraio, M, Sheibani, N, Schmitt, D, Silverstein, RL, Hajjar, DP, Cohen, PA, Frazier, WA, Hoff, HF, Hazen, SL

J Clin Invest 2000
16276419 CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions

Laugerette, F, Passilly-Degrace, P, Patris, B, Niot, I, Febbraio, M, Montmayeur, JP, Besnard, P

J. Clin. Invest. 2005
9834113 CD36 is required for phagocytosis of apoptotic cells by human macrophages that use either a phosphatidylserine receptor or the vitronectin receptor (alpha v beta 3)

Fadok, VA, Warner, ML, Bratton, DL, Henson, PM

J. Immunol. 1998
15690042 CD36 is a sensor of diacylglycerides

Hoebe, K, Georgel, P, Rutschmann, S, Du, X, Mudd, S, Crozat, K, Sovath, S, Shamel, L, Hartung, T, Zähringer, U, Beutler, B

Nature 2005
12105195 Identification of a novel family of oxidized phospholipids that serve as ligands for the macrophage scavenger receptor CD36

Podrez, EA, Poliakov, E, Shen, Z, Zhang, R, Deng, Y, Sun, M, Finton, PJ, Shan, L, Gugiu, B, Fox, PL, Hoff, HF, Salomon, RG, Hazen, SL

J Biol Chem 2002
7685021 CD36 is a receptor for oxidized low density lipoprotein

Endemann, G, Stanton, LW, Madden, KS, Bryant, CM, White, RT, Protter, AA

J Biol Chem 1993
11988484 CD36 mediates the cardiovascular action of growth hormone-releasing peptides in the heart

Bodart, V, Febbraio, M, Demers, A, McNicoll, N, Pohankova, P, Perreault, A, Sejlitz, T, Escher, E, Silverstein, RL, Lamontagne, D, Ong, H

Circ. Res. 2002
17101731 Oxidized phosphatidylserine-CD36 interactions play an essential role in macrophage-dependent phagocytosis of apoptotic cells

Greenberg, ME, Sun, M, Zhang, R, Febbraio, M, Silverstein, R, Hazen, SL

J Exp Med 2006
10938017 Oxidized LDL-induced NF-kappa B activation and subsequent expression of proinflammatory genes are defective in monocyte-derived macrophages from CD36-deficient patients

Janabi, M, Yamashita, S, Hirano, K, Sakai, N, Hiraoka, H, Matsumoto, K, Zhang, Z, Nozaki, S, Matsuzawa, Y

Arterioscler Thromb Vasc Biol 2000
19237602 Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36

Means, TK, Mylonakis, E, Tampakakis, E, Colvin, RA, Seung, E, Puckett, L, Tai, MF, Stewart, CR, Pukkila-Worley, R, Hickman, SE, Moore, KJ, Calderwood, SB, Hacohen, N, Luster, AD, El Khoury, J

J Exp Med 2009
7688729 Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36

Abumrad, NA, el-Maghrabi, MR, Amri, EZ, Lopez, E, Grimaldi, PA

J. Biol. Chem. 1993
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