RNF111 ubiquitinates SMAD7

Stable Identifier
R-HSA-2186785
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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RNF111 (Arkadia) polyubiquitinates SMAD7 (Koinuma et al. 2003). This was inferred from studies using recombinant mouse Smad7 and recombinant mouse Rnf111 expressed in human embryonic kidney cell line HEK293.

Literature References
PubMed ID Title Journal Year
14657019 Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7

Koinuma, D, Shinozaki, M, Komuro, A, Goto, K, Saitoh, M, Hanyu, A, Ebina, M, Nukiwa, T, Miyazawa, K, Imamura, T, Miyazono, K

EMBO J 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of SMAD7:RNF111 [nucleoplasm]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created