Reactome | NEDD4L ubiquitinates SMAD2/3

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NEDD4L ubiquitinates SMAD2/3 Show undefined attributes

authored	[InstanceEdit:2186634] Orlic-Milacic, M, 2012-04-04
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:2176500] Orlic-Milacic, M, 2012-04-02
dbId	2176502
displayName	NEDD4L ubiquitinates SMAD2/3
edited	[InstanceEdit:2187413] Jassal, B, 2012-04-10 [InstanceEdit:9773750] Orlic-Milacic, Marija, 2022-05-09
eventOf	[Pathway:R-HSA-2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-2176503] Degradation of SMAD2/3:SMAD4 complex - Homo sapiens
input	[Complex:R-HSA-2176495] p-T-2S-SMAD2,3:SMAD4:NEDDL4 [nucleoplasm] 2 × [DefinedSet:R-HSA-68524] Ub [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2176494] Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	NEDD4L ubiquitinates SMAD2/3
orthologousEvent	[Reaction:R-CEL-2176502] NEDD4L ubiquitinates SMAD2/3 - Caenorhabditis elegans [Reaction:R-DME-2176502] NEDD4L ubiquitinates SMAD2/3 - Drosophila melanogaster [Reaction:R-GGA-2176502] NEDD4L ubiquitinates SMAD2/3 - Gallus gallus [Reaction:R-CFA-2176502] NEDD4L ubiquitinates SMAD2/3 - Canis familiaris [Reaction:R-MMU-2176502] NEDD4L ubiquitinates SMAD2/3 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-2176420] NEDD4L [nucleoplasm] [Complex:R-HSA-2176504] Ub-p-T-2S-SMAD2,3:SMAD4 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-2176491] NEDD4L binds phosphorylated linker region of SMAD2/3 - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2250308] Huang, Tao, 2012-05-14 [InstanceEdit:9773670] Contreras, Osvaldo, 2022-05-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2176502
summation	[Summation:2176501] NEDD4L ubiquitinates nuclear SMAD2 and SMAD3 phosphorylated ...

Referrals

(hasEvent)	[Pathway:R-HSA-2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity
(precedingEvent)	[BlackBoxEvent:R-HSA-2176503] Degradation of SMAD2/3:SMAD4 complex [NegativePrecedingEvent:9754415] Futile Cycle: NEDD4L ubiquitinates SMAD2/3

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