Reactome | NEDD4L ubiquitinates SMAD2/3

Schema > Reaction > Entries

NEDD4L ubiquitinates SMAD2/3 Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10957228
displayName	NEDD4L ubiquitinates SMAD2/3
eventOf	[Pathway:R-CEL-2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-CEL-2176503] Degradation of SMAD2/3:SMAD4 complex - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-2176502] NEDD4L ubiquitinates SMAD2/3 - Homo sapiens
input	[Complex:R-CEL-2176495] p-T-2S-SMAD2,3:SMAD4:NEDDL4 [nucleoplasm] 2 × [DefinedSet:R-CEL-68524] Ub [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	NEDD4L ubiquitinates SMAD2/3
output	[EntityWithAccessionedSequence:R-CEL-2176420] NEDD4L [nucleoplasm] [Complex:R-CEL-2176504] Ub-p-T-2S-SMAD2,3:SMAD4 [nucleoplasm]
precedingEvent	[Reaction:R-CEL-2176491] NEDD4L binds phosphorylated linker region of SMAD2/3 - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-2176502
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity
(precedingEvent)	[BlackBoxEvent:R-CEL-2176503] Degradation of SMAD2/3:SMAD4 complex
(inferredTo)	[Reaction:R-HSA-2176502] NEDD4L ubiquitinates SMAD2/3