Reactome | FMO oxidises nucleophiles

Schema > Pathway > Entries

compartment	[Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10099077
displayName	FMO oxidises nucleophiles
eventOf	[Pathway:R-MMU-211945] Phase I - Functionalization of compounds - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:8764] xenobiotic metabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-217255] FMO1:FAD N-oxidises TAM - Mus musculus [Reaction:R-MMU-217258] FMO2:FAD:Mg2+ S-oxidises MTZ - Mus musculus [Reaction:R-MMU-139970] FMO3:FAD N-oxidises TMA to TMAO - Mus musculus
inferredFrom	[Pathway:R-HSA-217271] FMO oxidises nucleophiles - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	FMO oxidises nucleophiles
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-217271
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-MMU-211945] Phase I - Functionalization of compounds
(inferredTo)	[Pathway:R-HSA-217271] FMO oxidises nucleophiles

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