Reactome | Phosphorylation of GORASP1, GOLGA2 and RAB1A by CDK1:CCNB

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Phosphorylation of GORASP1, GOLGA2 and RAB1A by CDK1:CCNB Show undefined attributes

authored	[InstanceEdit:2424242] Orlic-Milacic, M, 2012-07-20
catalystActivity	[CatalystActivity:2311326] cyclin-dependent protein serine/threonine kinase activity of CCNB1,CCNB2:p-T161-CDK1 [cytosol]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:70101] cytosol
created	[InstanceEdit:2172181] Orlic-Milacic, M, 2012-03-28
dbId	2172183
displayName	Phosphorylation of GORASP1, GOLGA2 and RAB1A by CDK1:CCNB
edited	[InstanceEdit:2426592] Gillespie, ME, 2012-08-07
eventOf	[Pathway:R-HSA-162658] Golgi Cisternae Pericentriolar Stack Reorganization - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-2314569] GOLGA2 phosphorylated by CDK1 is unable to promote fusion of ER to Golgi transport vesicles with cis-Golgi - Homo sapiens [Reaction:R-HSA-2172194] Recruitment of PLK1 to phosphorylated GORASP1 (GRASP65) - Homo sapiens
inferredFrom	[Reaction:R-NUL-2422970] Phosphorylation of Gorasp1, Golga2 and RAB1A by CDK1:CCNB - Homo sapiens
input	5 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-2172177] GORASP1:GOLGA2:USO1:RAB1:GTP [Golgi membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:162969] Plk1 docking to GRASP65 phosphorylated by Cdk1 suggests a mechanism for Golgi checkpoint signalling [LiteratureReference:2245207] Cdc2 kinase directly phosphorylates the cis-Golgi matrix protein GM130 and is required for Golgi fragmentation in mitosis [LiteratureReference:2311330] The role of the tethering proteins p115 and GM130 in transport through the Golgi apparatus in vivo [LiteratureReference:2311341] Rab1 interaction with a GM130 effector complex regulates COPII vesicle cis--Golgi tethering [LiteratureReference:213386] The localization of human cyclins B1 and B2 determines CDK1 substrate specificity and neither enzyme requires MEK to disassemble the Golgi apparatus [LiteratureReference:2422384] The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b [LiteratureReference:2463817] Phosphorylation of two small GTP-binding proteins of the Rab family by p34cdc2 [LiteratureReference:2463829] Coordination of golgin tethering and SNARE assembly: GM130 binds syntaxin 5 in a p115-regulated manner [LiteratureReference:2463836] The vesicle docking protein p115 binds GM130, a cis-Golgi matrix protein, in a mitotically regulated manner [LiteratureReference:213384] Human cyclins B1 and B2 are localized to strikingly different structures: B1 to microtubules, B2 primarily to the Golgi apparatus
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of GORASP1, GOLGA2 and RAB1A by CDK1:CCNB
output	5 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-2172185] p-T216,S274,S373-GORASP1:p-S37-GOLGA2:p-RAB1:GTP [Golgi membrane] [Complex:R-HSA-2311342] USO1 homodimer [ER to Golgi transport vesicle membrane]
precedingEvent	[Reaction:R-HSA-170161] Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B - Homo sapiens
releaseDate	2012-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2463852] Wang, Yanzhuang, 2012-08-19 [InstanceEdit:2463846] Colanzi, Antonino, 2012-08-21 [InstanceEdit:2507813] Malhotra, Vivek, 2012-08-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2172183
summation	[Summation:2311346] GORASP1 (GRASP65) and GOLGA2 (GM130) form a complex on cis-G...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-2314569] GOLGA2 phosphorylated by CDK1 is unable to promote fusion of ER to Golgi transport vesicles with cis-Golgi [Reaction:R-HSA-2172194] Recruitment of PLK1 to phosphorylated GORASP1 (GRASP65)
(hasEvent)	[Pathway:R-HSA-162658] Golgi Cisternae Pericentriolar Stack Reorganization
(inferredTo)	[Reaction:R-NUL-2422970] Phosphorylation of Gorasp1, Golga2 and RAB1A by CDK1:CCNB

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