Reactome | Phosphorylation of Gorasp1, Golga2 and RAB1A by CDK1:CCNB

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Phosphorylation of Gorasp1, Golga2 and RAB1A by CDK1:CCNB Show undefined attributes

authored	[InstanceEdit:2424242] Orlic-Milacic, M, 2012-07-20
catalystActivity	[CatalystActivity:2311326] cyclin-dependent protein serine/threonine kinase activity of CCNB1,CCNB2:p-T161-CDK1 [cytosol]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:70101] cytosol
created	[InstanceEdit:2422971] Orlic-Milacic, M, 2012-07-19
dbId	2422970
displayName	Phosphorylation of Gorasp1, Golga2 and RAB1A by CDK1:CCNB
edited	[InstanceEdit:2426592] Gillespie, ME, 2012-08-07
input	5 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-NUL-2422980] Gorasp1:Golga2:Uso1:RAB1:GTP [Golgi membrane]
isChimeric	true
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:162969] Plk1 docking to GRASP65 phosphorylated by Cdk1 suggests a mechanism for Golgi checkpoint signalling [LiteratureReference:2245207] Cdc2 kinase directly phosphorylates the cis-Golgi matrix protein GM130 and is required for Golgi fragmentation in mitosis [LiteratureReference:2311330] The role of the tethering proteins p115 and GM130 in transport through the Golgi apparatus in vivo [LiteratureReference:2311341] Rab1 interaction with a GM130 effector complex regulates COPII vesicle cis--Golgi tethering [LiteratureReference:213386] The localization of human cyclins B1 and B2 determines CDK1 substrate specificity and neither enzyme requires MEK to disassemble the Golgi apparatus [LiteratureReference:2422384] The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b [LiteratureReference:2463817] Phosphorylation of two small GTP-binding proteins of the Rab family by p34cdc2 [LiteratureReference:213384] Human cyclins B1 and B2 are localized to strikingly different structures: B1 to microtubules, B2 primarily to the Golgi apparatus
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of Gorasp1, Golga2 and RAB1A by CDK1:CCNB
orthologousEvent	[Reaction:R-HSA-2172183] Phosphorylation of GORASP1, GOLGA2 and RAB1A by CDK1:CCNB - Homo sapiens
output	5 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-NUL-2422975] p-S217,277,376-Gorasp1:p-S37-Golga2:p-RAB1:GTP [Golgi membrane] [Complex:R-RNO-2422979] Uso1 homodimer [ER to Golgi transport vesicle membrane]
releaseDate	2012-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2463852] Wang, Yanzhuang, 2012-08-19 [InstanceEdit:2463846] Colanzi, Antonino, 2012-08-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens [Species:48895] Rattus norvegicus
stId	R-NUL-2422970
summation	[Summation:2422977] The existence of Gorasp1:Golga2:Uso1:Rab1:GTP complex was es...