Reactome | abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+

Schema > Reaction > Entries

abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ Show undefined attributes

catalystActivity	[CatalystActivity:10387133] alcohol dehydrogenase (NAD+) activity of ADH1A:2Zn2+ dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10387135
displayName	abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+
eventOf	[Pathway:R-BTA-2161541] Abacavir metabolism - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-2162078] abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ - Homo sapiens
input	[ChemicalDrug:R-ALL-2161185] abacavir [cytosol] 2 × [SimpleEntity:R-ALL-29360] NAD+ [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ Oxidation of abacavir to abacavir 5'-carboxylate
output	[SimpleEntity:R-ALL-2162081] abacavir 5'-carboxylic acid [cytosol] 2 × [SimpleEntity:R-ALL-70106] H+ [cytosol] 2 × [SimpleEntity:R-ALL-73473] NADH [cytosol]
precedingEvent	[Reaction:R-BTA-2161500] abacavir [extracellular] => abacavir [cytosol] - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-2162078
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-2161541] Abacavir metabolism
(inferredTo)	[Reaction:R-HSA-2162078] abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+

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