Reactome | Arachidonate is hydroxylated to 19-HETE by CYP(2)

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Arachidonate is hydroxylated to 19-HETE by CYP(2) Show undefined attributes

authored	[InstanceEdit:2142839] Williams, MG, 2012-02-24
catalystActivity	[CatalystActivity:2162026] monooxygenase activity of CYP(2) [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:2161780] Williams, MG, 2012-03-14
crossReference	[DatabaseIdentifier:9915972] RHEA:39760
dbId	2161814
displayName	Arachidonate is hydroxylated to 19-HETE by CYP(2)
edited	[InstanceEdit:2142839] Williams, MG, 2012-02-24
eventOf	[Pathway:R-HSA-2142816] Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) - Homo sapiens
input	[SimpleEntity:R-ALL-140356] AA [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-156540] H+ [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113601] NADPH [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113534] O2 [endoplasmic reticulum lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2161920] Cytochromes P450 with bisallylic hydroxylation activity on arachidonic and linoleic acids studied with human recombinant enzymes and with human and rat liver microsomes [LiteratureReference:2161835] Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension [LiteratureReference:216555] CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids [LiteratureReference:2162004] Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Arachidonate is hydroxylated to 19-HETE by CYP(2) (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced (NADPH--hemoprotein reductase) => 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized (NADPH--hemoprotein reductase)
orthologousEvent	[Reaction:R-DDI-2161814] Arachidonate is hydroxylated to 19-HETE by CYP(2) - Dictyostelium discoideum [Reaction:R-CEL-2161814] Arachidonate is hydroxylated to 19-HETE by CYP(2) - Caenorhabditis elegans [Reaction:R-DME-2161814] Arachidonate is hydroxylated to 19-HETE by CYP(2) - Drosophila melanogaster [Reaction:R-GGA-2161814] Arachidonate is hydroxylated to 19-HETE by CYP(2) - Gallus gallus [Reaction:R-XTR-2161814] Arachidonate is hydroxylated to 19-HETE by CYP(2) - Xenopus tropicalis [Reaction:R-DRE-2161814] Arachidonate is hydroxylated to 19-HETE by CYP(2) - Danio rerio [Reaction:R-SSC-2161814] Arachidonate is hydroxylated to 19-HETE by CYP(2) - Sus scrofa [Reaction:R-BTA-2161814] Arachidonate is hydroxylated to 19-HETE by CYP(2) - Bos taurus [Reaction:R-CFA-2161814] Arachidonate is hydroxylated to 19-HETE by CYP(2) - Canis familiaris [Reaction:R-RNO-2161814] Arachidonate is hydroxylated to 19-HETE by CYP(2) - Rattus norvegicus [Reaction:R-MMU-2161814] Arachidonate is hydroxylated to 19-HETE by CYP(2) - Mus musculus
output	[SimpleEntity:R-ALL-2142836] 19-HETE [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113564] NADP+ [endoplasmic reticulum lumen]
precedingEvent	[Reaction:R-HSA-111883] PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine - Homo sapiens
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2569042] Rush, MG, 2012-11-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2161814
summation	[Summation:2161906] Several cytochrome P450s (CYPs) convert arachidonate to 19-h...
updateTrackers	[UpdateTracker:9919408] Update Tracker - [Reaction:2161814] Arachidonate is hydroxylated to 19-HETE by CYP(2) - v90:[modifyText]

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(updatedInstance)	[UpdateTracker:9919408] Update Tracker - [Reaction:2161814] Arachidonate is hydroxylated to 19-HETE by CYP(2) - v90:[modifyText]
(hasEvent)	[Pathway:R-HSA-2142816] Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)