Arachidonic acid is hydroxylated to 19-HETE by CYP(2)

Stable Identifier
R-HSA-2161814
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Several cytochrome P450s (CYPs) convert arachidonic acid to 19-hydroxyeicosatetraenoic acid (19-HETE). The CYPs and their references are as follows: CYP2C8 (Bylund et al. 1998); CYP2C9 (Bylund et al. 1998); CYP2C19 (Bylund et al. 1998); CYP4A11 (Gainer et al. 2005); CYP2U1 (Chuang et al. 2004); CYP1A1, CYP1A2, CYP1B1 (Choudhary et al. 2004).

Literature References
PubMed ID Title Journal Year
15611369 Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension

Wang, Y, Dawson, EP, Cupples, LA, Bellamine, A, Brown, NJ, Demissie, S, Womble, KE, Gainer, JV, Guo, CY, Grant, SW, Capdevila, JH, Waterman, MR, O'Donnell, CJ

Circulation 2005
14660610 CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids

Taimi, M, Helvig, C, Petkovich, M, Chuang, SS, Korczak, B, Ramshaw, HA, Jones, G, Collop, AH, Amad, M, White, JA

J Biol Chem 2004
9435160 Cytochromes P450 with bisallylic hydroxylation activity on arachidonic and linoleic acids studied with human recombinant enzymes and with human and rat liver microsomes

Oliw, EH, Bylund, J, Valmsen, K, Kunz, T

J Pharmacol Exp Ther 1998
15258110 Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1

Stoilov, I, Choudhary, D, Schenkman, JB, Sarfarazi, M, Jansson, I

Drug Metab Dispos 2004
Participants
Participates
Catalyst Activity

monooxygenase activity of CYP(2) [endoplasmic reticulum membrane]

Orthologous Events
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