Reactome | ALOX12 oxidises LTA4 to LXA4

Schema > Reaction > Entries

ALOX12 oxidises LTA4 to LXA4 Show undefined attributes

authored	[InstanceEdit:2142839] Williams, MG, 2012-02-24
catalystActivity	[CatalystActivity:2161800] oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen of ALOX12:Fe2+ [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2161780] Williams, MG, 2012-03-14
crossReference	[DatabaseIdentifier:12668422] RHEA:48585 [DatabaseIdentifier:9916378] RHEA:48585
dbId	2161775
displayName	ALOX12 oxidises LTA4 to LXA4
edited	[InstanceEdit:2142839] Williams, MG, 2012-02-24
eventOf	[Pathway:R-HSA-2142700] Biosynthesis of Lipoxins (LX) - Homo sapiens
followingEvent	[Reaction:R-HSA-2161779] LXA4 is oxidised to 15k-LXA4 by HPGD - Homo sapiens
input	2 × [SimpleEntity:R-ALL-29356] H2O [cytosol] 2 × [SimpleEntity:R-ALL-9032038] LTA4 [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2161873] Lipoxin synthase activity of human platelet 12-lipoxygenase [LiteratureReference:2162054] Lipoxin formation during human neutrophil-platelet interactions. Evidence for the transformation of leukotriene A4 by platelet 12-lipoxygenase in vitro [LiteratureReference:2161812] Evidence for a 5(6)-epoxytetraene intermediate in the biosynthesis of lipoxins in human leukocytes. Conversion into lipoxin A by cytosolic epoxide hydrolase
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	ALOX12 oxidises LTA4 to LXA4 2 H2O + 2 leukotriene A4 + O2 => 2 lipoxin A4
orthologousEvent	[Reaction:R-DDI-2161775] ALOX12 oxidises LTA4 to LXA4 - Dictyostelium discoideum [Reaction:R-DRE-2161775] ALOX12 oxidises LTA4 to LXA4 - Danio rerio [Reaction:R-SSC-2161775] ALOX12 oxidises LTA4 to LXA4 - Sus scrofa [Reaction:R-BTA-2161775] ALOX12 oxidises LTA4 to LXA4 - Bos taurus [Reaction:R-CFA-2161775] ALOX12 oxidises LTA4 to LXA4 - Canis familiaris [Reaction:R-RNO-2161775] ALOX12 oxidises LTA4 to LXA4 - Rattus norvegicus [Reaction:R-MMU-2161775] ALOX12 oxidises LTA4 to LXA4 - Mus musculus
output	2 × [SimpleEntity:R-ALL-2161759] LXA4 [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-9032036] LTA4 translocates from neutrophil cytosol to platelet cytosol - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2569042] Rush, MG, 2012-11-10 [InstanceEdit:9037799] Hansen, Trond Vidar, 2018-02-21 [InstanceEdit:9917333] Hill, David P, 2024-08-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2161775
summation	[Summation:2162021] Arachidonate 12-lipoxygenase, 12S-type (ALOX12) catalyses th...
updateTrackers	[UpdateTracker:9778825] Update Tracker - [Reaction:2161775] ALOX12 oxidises LTA4 to LXA4/B4 - v67:[addInput] [UpdateTracker:9779924] Update Tracker - [Reaction:2161775] ALOX12 oxidises LTA4 to LXA4/B4 - v64:[add_removeInput] [UpdateTracker:9919345] Update Tracker - [Reaction:2161775] ALOX12 oxidises LTA4 to LXA4 - v90:[add_removeOutput, modifyText, removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9778825] Update Tracker - [Reaction:2161775] ALOX12 oxidises LTA4 to LXA4/B4 - v67:[addInput] [UpdateTracker:9779924] Update Tracker - [Reaction:2161775] ALOX12 oxidises LTA4 to LXA4/B4 - v64:[add_removeInput] [UpdateTracker:9919345] Update Tracker - [Reaction:2161775] ALOX12 oxidises LTA4 to LXA4 - v90:[add_removeOutput, modifyText, removeInput]
(hasEvent)	[Pathway:R-HSA-2142700] Biosynthesis of Lipoxins (LX)
(precedingEvent)	[Reaction:R-HSA-2161779] LXA4 is oxidised to 15k-LXA4 by HPGD