Reactome | ALOX12 oxidises LTA4 to LXA4

ALOX12 oxidises LTA4 to LXA4

Stable Identifier

R-HSA-2161775

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

2 H2O + 2 leukotriene A4 + O2 => 2 lipoxin A4

ReviewStatus

5/5

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Arachidonate 12-lipoxygenase, 12S-type (ALOX12) catalyses the conversion of leukotriene A4 (LTA4) into the lipoxin LXA4, which has its third hydroxyl positioned at C-6 (Romano et al. 1993, Serhan & Sheppard 1990). One of the reaction intermediates of this process might be 5S,6S-epoxy-15S-hydroxy-7E,9E,11Z,13E-eicosatetraenoic acid (5,6-Ep-15S-HETE) (Puustinen et al. 1986). However, its generation from LTA4 is unclear but it can be hydrolysed to form the lipoxins.

Literature References

PubMed ID	Title	Journal	Year
2155925	Lipoxin formation during human neutrophil-platelet interactions. Evidence for the transformation of leukotriene A4 by platelet 12-lipoxygenase in vitro Serhan, CN, Sheppard, KA	J Clin Invest	1990
3770188	Evidence for a 5(6)-epoxytetraene intermediate in the biosynthesis of lipoxins in human leukocytes. Conversion into lipoxin A by cytosolic epoxide hydrolase Puustinen, T, Webber, SE, Nicolaou, KC, Haeggström, JZ, Serhan, CN, Samuelsson, B	FEBS Lett	1986
8250832	Lipoxin synthase activity of human platelet 12-lipoxygenase Romano, M, Chen, XS, Takahashi, Y, Yamamoto, S, Funk, CD, Serhan, CN	Biochem J	1993

Participants

Input

Output

x 2 LXA4 [cytosol]

Participates

as an event of

Biosynthesis of Lipoxins (LX) (Homo sapiens)

Catalyst Activity

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen of ALOX12:Fe2+ [cytosol]

Physical Entity

ALOX12:Fe2+ [cytosol] (Homo sapiens)

Activity

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen (GO:0016702)

Orthologous Events

ALOX12 oxidises LTA4 to LXA4 (Bos taurus)

ALOX12 oxidises LTA4 to LXA4 (Canis familiaris)

ALOX12 oxidises LTA4 to LXA4 (Danio rerio)

ALOX12 oxidises LTA4 to LXA4 (Dictyostelium discoideum)

ALOX12 oxidises LTA4 to LXA4 (Mus musculus)

ALOX12 oxidises LTA4 to LXA4 (Rattus norvegicus)

ALOX12 oxidises LTA4 to LXA4 (Sus scrofa)