ALOX12 oxidises LTA4 to LXA4/B4

Stable Identifier
R-HSA-2161775
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Arachidonate 12-lipoxygenase, 12S-type (ALOX12) catalyses the conversion of leukotriene A4 (LTA4) into the lipoxins LXA4, which has its third hydroxyl positioned at C-6 and LXB4, which has it positioned at C-14 (Romano et al. 1993, Serhan & Sheppard 1990). One of the reaction intermediates of this process might be 5S,6S-epoxy-15S-hydroxy-7E,9E,11Z,13E-eicosatetraenoic acid (5,6-Ep-15S-HETE) (Puustinen et al. 1986). However, its generation from LTA4 is unclear but it can be hydrolysed to form the lipoxins.

Literature References
PubMed ID Title Journal Year
3770188 Evidence for a 5(6)-epoxytetraene intermediate in the biosynthesis of lipoxins in human leukocytes. Conversion into lipoxin A by cytosolic epoxide hydrolase

Puustinen, T, Webber, SE, Nicolaou, KC, Haeggström, JZ, Serhan, CN, Samuelsson, B

FEBS Lett 1986
2155925 Lipoxin formation during human neutrophil-platelet interactions. Evidence for the transformation of leukotriene A4 by platelet 12-lipoxygenase in vitro

Serhan, CN, Sheppard, KA

J Clin Invest 1990
8250832 Lipoxin synthase activity of human platelet 12-lipoxygenase

Romano, M, Chen, XS, Takahashi, Y, Yamamoto, S, Funk, CD, Serhan, CN

Biochem J 1993
Participants
Participates
Catalyst Activity

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen of ALOX12:Fe2+ [cytosol]

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