ALOX12 oxidises LTA4 to LXA4/B4

Stable Identifier
Reaction [transition]
Homo sapiens
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Arachidonate 12-lipoxygenase, 12S-type (ALOX12) catalyses the conversion of leukotriene A4 (LTA4) into the lipoxins LXA4, which has its third hydroxyl positioned at C-6 and LXB4, which has it positioned at C-14 (Romano et al. 1993, Serhan & Sheppard 1990). One of the reaction intermediates of this process might be 5S,6S-epoxy-15S-hydroxy-7E,9E,11Z,13E-eicosatetraenoic acid (5,6-Ep-15S-HETE) (Puustinen et al. 1986). However, its generation from LTA4 is unclear but it can be hydrolysed to form the lipoxins.
Literature References
PubMed ID Title Journal Year
2155925 Lipoxin formation during human neutrophil-platelet interactions. Evidence for the transformation of leukotriene A4 by platelet 12-lipoxygenase in vitro

Serhan, CN, Sheppard, KA

J Clin Invest 1990
3770188 Evidence for a 5(6)-epoxytetraene intermediate in the biosynthesis of lipoxins in human leukocytes. Conversion into lipoxin A by cytosolic epoxide hydrolase

Nicolaou, KC, Webber, SE, Serhan, CN, Haeggström, JZ, Puustinen, T, Samuelsson, B

FEBS Lett 1986
8250832 Lipoxin synthase activity of human platelet 12-lipoxygenase

Serhan, CN, Takahashi, Y, Romano, M, Yamamoto, S, Funk, CD, Chen, XS

Biochem J 1993
Catalyst Activity

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen of ALOX12:Fe2+ [cytosol]

Orthologous Events
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